The use of light activated antimicrobials to prevent catheter related infection

使用光激活抗菌剂预防导管相关感染

• 批准号: G0902208/1
• 负责人: Ivan Parkin
• 金额: $ 98.21万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902208%2F1
• 关键词: use; light; activated; antimicrobials; prevent

This project is focussed on reducing catheter acquired infection or CAI. These infections are widespread in the NHS and are particularly prevelant in newborns and the elderly. Our project seeks to reduce these infections through a new approach that uses a light source and a new class of catheter. This catheter has embedded dye molecules that under the action of light produce species that are toxic to bacteria. These catheters are self sterilising and most importantly show the ability to resist the biofilm formation that is the precursor to infection. It has been determined that catheter born infections are the most common cause of hospital acquired infection in the UK.

该项目的重点是减少导管获得的感染或CAI。这些感染在NHS中是广泛的，在新生儿和老年人中尤其是前期的。我们的项目旨在通过采用光源和新导管的新方法来减少这些感染。该导管具有嵌入的染料分子，在光的作用下产生对细菌有毒的物种。这些导管正在自我消毒，最重要的是表明了抵抗感染前体的生物膜形成的能力。已经确定，导管出生的感染是英国医院获得感染的最常见原因。