Aging and Sympathetic Vasoconstriction: Rest vs Exercise

衰老与交感血管收缩：休息与运动

• 批准号: 6946842
• 负责人: FRANK A DINENNO
• 金额: $ 11.9万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946842
• 关键词: aerobic exercise; age difference; aging; alpha adrenergic receptor; clinical research; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; leg; nitric oxide; oxidative stress; rest; sympathetic nervous system; vascular smooth muscle nervous control; vasoconstriction; young adult human (21-34)

DESCRIPTION (provided by applicant): Candidate: The candidate, Frank A. Dinenno, Ph.D., is a physiologist currently supported by an individual NRSA from NIA. Dr. Dinenno's previous and current research focus has been on sympathetic neural control of the circulation, with specific emphasis on how these control mechanisms are modulated by advancing age and regular physical activity in humans. His immediate goal is to acquire new research and professional skills to better prepare and help him achieve his long-term goal of developing a successful independent extramurally-funded research program on aging and cardiovascular function. This proposed KO1 should provide Dr. Dinenno the necessary training to achieve his goal. Career Development Plan: Dr. Dinenno's research career development training activities will consist of (1) acquiring new research skills associated with and complimentary to the proposed research plan; and (2) structured research- and professional skills-related activities. Environment: The environment for Dr. Dinenno's training will be outstanding. The Sponsor (Dr. Joyner) and consulting mentors are engaged in biomedical research and are extramurally-funded from NIH. All are established scientists with strong records of successful mentoring in biomedical research, three of the six are experts in aging research. Support from the General Clinical Research Center will enhance the training environment. Research: The following specific aims will be addressed: 1) to determine whether whole-leg alpha-adrenergic receptor responsiveness is reduced with age under resting conditions in healthy humans, and whether this is specific for cq- or c2-adrenergic receptors; (2) to determine whether the ability to blunt-adrenergic vasoconstriction during large muscle dynamic exercise is impaired in older adults and (3) whether this impairment is due to age-related reductions in nitric oxide bioavailability mediated via elevations in oxidative stress; and (4) to determine whether a program of regular aerobic exercise improves the ability of previously sedentary older adults to blunt sympathetic vasoconstriction at rest and during exercise. The expected results should yield new information regarding sympathetic neural control of the circulation at rest and during exercise in aging humans, and the intervention study should yield novel information about training-induced adaptations and peripheral circulatory control in older adults.

描述（由申请人提供）： 候选人： 候选人 Frank A. Dinenno 博士是一名生理学家，目前得到 NIA 个人 NRSA 的支持。 Dinenno 博士之前和当前的研究重点是循环的交感神经控制，特别强调这些控制机制如何通过人类年龄的增长和定期身体活动来调节。他的近期目标是获得新的研究和专业技能，以更好地准备并帮助他实现长期目标，即开发一个成功的独立的外部资助的衰老和心血管功能研究项目。拟议的 KO1 应该为 Dinenno 博士提供必要的培训以实现他的目标。职业发展计划：Dinenno 博士的研究职业发展培训活动将包括 (1) 获得与拟议研究计划相关且互补的新研究技能； (2) 结构化的研究和专业技能相关活动。环境：Dinenno博士的培训环境非常好。发起人（Joyner 博士）和咨询导师从事生物医学研究，并获得 NIH 的校外资助。他们都是知名科学家，在生物医学研究方面拥有成功指导的良好记录，其中六人中的三人是衰老研究专家。综合临床研究中心的支持将改善培训环境。研究：将解决以下具体目标：1）确定健康人在静息条件下，全腿α-肾上腺素能受体反应性是否随着年龄的增长而降低，以及这是否针对cq-或c2-肾上腺素能受体； (2) 确定老年人在大肌肉动态运动期间减弱肾上腺素能血管收缩的能力是否受损，以及 (3) 这种损害是否是由于氧化应激升高介导的与年龄相关的一氧化氮生物利用度降低所致； (4)确定定期有氧运动计划是否可以提高以前久坐的老年人在休息和运动时减弱交感血管收缩的能力。预期的结果应该会产生关于老年人休息和运动期间交感神经控制循环的新信息，并且干预研究应该产生关于老年人训练引起的适应和外周循环控制的新信息。