Risk Factors for Anabolic-Androgenic Steroid Abuse

合成代谢雄激素类固醇滥用的危险因素

基本信息

批准号：
7379970
负责人：
HARRISON G POPE
金额：
$ 32.91万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7379970
关键词：
Address Adolescent Adverse effects Advertising Alcohol or Other Drugs use American Anabolic steroids Appearance Appendix Athletic Attention Blinded Body Dysmorphic Disorder Body Image Childhood Cohort Studies Data Disease Doctor of Medicine Drug abuse Drug usage Eating Disorders Education Ensure Family Funding Hepatotoxicity Hormones Illicit Drugs Individual Institutes Intervention Studies Interview Interviewer Investigation Lead Lipoproteins Malignant neoplasm of prostate Measures Medical Mental disorders Mood Disorders Morbidity - disease rate Muscle Neoplasms Neurosecretory Systems Numbers Observer Variation Outcome Patient Self-Report Pharmaceutical Preparations Pilot Projects Population Prevention program Public Health Purpose Recording of previous events Recruitment Activity Reporting Research Research Personnel Resources Risk Risk Factors Risk-Taking Sampling Structure Students Substance abuse problem Supervision Surveys Symptoms Syndrome Target Populations Television Testing Testosterone Time Violence Withdrawal Woman anti social base boys case control cohort design experience field study high school improved male men peer prevent prospective response steroid dependence trait

项目摘要

DESCRIPTION (provided by applicant): Illicit anabolic-androgenic steroid (AAS) use represents an important public health problem; NIDA has recently funded a major public education campaign to counter AAS use, with television advertising in English and Spanish. Surprisingly, however, we are not aware of any NIDA-funded studies of illicit AAS users (aside from a team-based substance abuse prevention program) in the last four fiscal years. Because of the limited available research, risk factors for illicit AAS use are poorly understood. In a recent pilot study, we found that AAS use may be associated with two clusters of risk factors, an antisocial cluster and a body image cluster. To test these hypotheses, we propose a cross-sectional cohort study- an advantageous and underutilized design, which we show is equal in validity to the more traditional case control design, but particularly suited for the study of risk factors in our setting. We will assess 300 men, drawn from a population of regular weightlifters, and shown by our pilot data to contain approximately 50% of AAS users. To minimize observer bias, one interviewer will assess subjects for the outcome variable (history of AAS use), and a separate blinded interviewer will assess subjects for all exposure variables (childhood and adolescent attributes that may be risk factors for AAS use). These assessments will use a battery of structured personal interviews and self-report measures, developed from our pilot study and extensive previous AAS research. We hypothesize that AAS use will be significantly associated with 1) childhood and adolescent antisocial traits and associated attributes, including parental substance use, lack of parental supervision, risk-taking, and drug use among peers; and 2) childhood and adolescent body image concerns and associated attributes, including eating disorders, body dysmorphic disorder, and other disorders in the obsessive-compulsive spectrum. We will also test the secondary hypothesis that the antisocial cluster predicts drug use in general, whereas the body image cluster predicts AAS use in particular. Findings from this study will lead to more focused and efficient strategies for 1) identifying boys and young men most likely to use AAS; 2) targeting populations at greatest risk, to ensure optimum deployment of educational resources for reducing AAS use; 3) treating psychiatric disorders (such as body image disorders) in individuals at high risk for AAS use; and 4) designing subsequent prospective intervention studies of strategies to prevent AAS use.

描述（由申请人提供）：非法合成代谢 - 丁香类固醇（AAS）的使用代表了一个重要的公共卫生问题； NIDA最近资助了一项重大的公共教育运动，以应对AAS的使用，并用英语和西班牙语进行电视广告。但是，令人惊讶的是，在过去的四年中，我们不知道对非法AAS使用者（除了基于团队的药物预防计划）进行了任何NIDA资助的研究。由于可用的研究有限，因此对非法AAS使用的危险因素知之甚少。在最近的一项试点研究中，我们发现使用AA的使用可能与两个危险因素簇，一个反社会簇和身体形象簇有关。为了检验这些假设，我们提出了一项横截面队列研究 - 一种有利且充分利用的设计，我们表明的有效性与更传统的案例控制设计相等，但尤其适合在我们的环境中研究风险因素。我们将评估300名男性，这些男性是从一系列常规举重者中吸引的，并由我们的飞行员数据显示，其中包含大约50％的AAS使用者。为了最大程度地减少观察者偏见，一位访调员将评估结果变量的受试者（AAS使用的历史），单独的失明访调员将评估所有暴露变量的受试者（儿童和青少年属性可能是AAS使用的风险因素）。这些评估将利用一系列结构化的个人访谈和自我报告措施，这些措施是根据我们的试点研究和以前的AAS研究开发的。我们假设AA的使用将与1）儿童和青少年的反社会特征和相关属性显着相关，包括父母的药物使用，缺乏父母的监督，冒险和同龄人的药物使用； 2）童年和青春期的身体形象问题和相关属性，包括饮食失调，身体畸形疾病以及强迫症中的其他疾病。我们还将检验一个次要假设，即反社会聚类通常可以预测药物的使用，而人体图像簇特别预测了AAS的使用。这项研究的结果将为1）确定最有可能使用AA的男孩和年轻男性提供更加集中和有效的策略； 2）针对最大风险的人群，以确保最佳的教育资源来减少AAS的使用； 3）治疗AAS高风险的个体中的精神疾病（例如身体形象障碍）； 4）设计随后的前瞻性干预研究，以防止AAS使用。