A Compact X-ray Station for Protein Crystallography

用于蛋白质晶体学的紧凑型 X 射线站

• 批准号: 7091930
• 负责人: JEFFREY RIFKIN
• 金额: $ 244.95万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091930
• 关键词: X ray crystallography; bioengineering /biomedical engineering; biomedical equipment development; electromagnetic radiation; macromolecule; miniature biomedical equipment; optics; synchrotrons

DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.

描述（由申请人提供）：该快速 SBIR 的目的是开发一种用于大分子晶体学的创新型紧凑型 X 射线站 (CXS)。该站接受紧凑光源（微型同步加速器）的输出 X 射线束，并将 X 射线束传送到 3 个终端站。每条光束线都容纳一个集成的商用衍射仪。 2 个侧站均接收 30 微米 rms 光斑中的可调谐单色 X 射线束。前站接收聚焦的高通量窄带 X 射线束。每个 X 射线束的可调范围为 7 至 16 keV，并将提供与同步加速器束线相当的通量和能量分辨率。光束线可以单独运行、成对运行或全部 3 条同时运行。在第一阶段，我们将设计 X 射线光学系统并通过实验测试新型可调谐聚焦单色仪。在第二阶段，我们将建造 X 射线光学器件和终端站，集成商用衍射仪并全面测试终端站。 CXS 是一款创新、功能强大的“交钥匙”X 射线系统，将为家庭实验室提供 3 条“同步加速器”光束线，用于大分子晶体学； 2 条光束线将具有用于单波长或多波长反常色散实验的通量、可调性和能量分辨率，第三条光束线将针对更高通量筛选进行优化。