A Tunable, Tabletop, Synchrotron Light Source

可调谐桌面同步加速器光源

• 批准号: 6752641
• 负责人: JEFFREY RIFKIN
• 金额: $ 355.84万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6752641
• 关键词: X ray; X ray crystallography; bioengineering /biomedical engineering; biomedical equipment development; computer system design /evaluation; energy source; lasers; optics; synchrotrons

DESCRIPTION (provided by applicant): Intense x-rays from Synchrotron Radiation sources are having an increasingly revolutionary impact on science and technology, and in particular, macromolecular crystallography. Recent research at Stanford University has led to a new x-ray source that will have a major impact on protein structure determination for health care. The Compact Light Source (CLS) is a breakthrough technology that offers a tunable, tabletop x-ray source that could be used like an x-ray beamline at a large light source. The compact size is achieved through the marriage of a laser and a miniature electron storage ring. The photon flux on a sample will be comparable to many synchrotron beamlines. The overall goals of this proposal are to first engineer, then prototype, and finally demonstrate the performance of the CLS. In Phase I, we will test the laser system and design the electron storage ring. In Phase II, we will build the storage ring, integrate the laser system, and demonstrate x-ray production. The CLS will also provide the foundation for future x-ray applications in the health care field. With the CLS, clinical applications such as non-invasive coronary angiography, diffraction-enhanced imaging, and improved cancer detection could be moved from the laboratory into hospitals throughout the nation.

描述（由申请人提供）：来自同步加速器辐射源的强 X 射线对科学技术，特别是大分子晶体学产生越来越大的革命性影响。斯坦福大学最近的研究开发出了一种新的 X 射线源，它将对医疗保健领域的蛋白质结构测定产生重大影响。紧凑光源 (CLS) 是一项突破性技术，提供可调谐桌面 X 射线源，可像大型光源的 X 射线光束线一样使用。紧凑的尺寸是通过激光器和微型电子存储环的结合实现的。样品上的光子通量将与许多同步加速器光束线相当。该提案的总体目标是首先进行工程设计，然后进行原型设计，最后展示 CLS 的性能。在第一阶段，我们将测试激光系统并设计电子存储环。在第二阶段，我们将建造存储环、集成激光系统并演示X射线的产生。 CLS 还将为未来 X 射线在医疗保健领域的应用奠定基础。借助 CLS，无创冠状动脉造影、衍射增强成像和改进的癌症检测等临床应用可以从实验室转移到全国各地的医院。