A Compact X-ray Station for Protein Crystallography

用于蛋白质晶体学的紧凑型 X 射线站

• 批准号: 7911573
• 负责人: JEFFREY RIFKIN
• 金额: $ 118.44万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7911573
• 关键词: Capital; Communities; Crystallography; Development; Elements; Engineering; Equipment; Grant; Home environment; Institution; Intercept; Investments; Laboratories; Light; Mechanics; Motion; National Institute of General Medical Sciences; Operative Surgical Procedures; Optics; Output; Performance; Phase; Principal Investigator; Productivity; Protein Structure Initiative; Proteins; Proteomics; Research; Resolution; Resources; Roentgen Rays; Running; Screening procedure; Services; Side; Small Business Innovation Research Grant; Source; Spottings; Structure; Synchrotrons; System; Systems Integration; Testing; base; beamline; cost; design; drug discovery; engineering design; innovation; instrument; programs; prototype; research study; structural biology; structural genomics

DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.

描述（由申请人提供）：该快速 SBIR 的目的是开发一种用于大分子晶体学的创新型紧凑型 X 射线站 (CXS)。该站接受紧凑光源（微型同步加速器）的输出 X 射线束，并将 X 射线束传送到 3 个终端站。每条光束线都容纳一个集成的商用衍射仪。 2 个侧站均接收 30 微米 rms 光斑中的可调谐单色 X 射线束。前站接收聚焦的高通量窄带 X 射线束。每个 X 射线束的可调范围为 7 至 16 keV，并将提供与同步加速器束线相当的通量和能量分辨率。光束线可以单独运行、成对运行或全部 3 条同时运行。在第一阶段，我们将设计 X 射线光学系统并通过实验测试新型可调谐聚焦单色仪。在第二阶段，我们将建造 X 射线光学器件和终端站，集成商用衍射仪并全面测试终端站。 CXS 是一款创新、功能强大的“交钥匙”X 射线系统，将为家庭实验室提供 3 条“同步加速器”光束线，用于大分子晶体学； 2 条光束线将具有用于单波长或多波长反常色散实验的通量、可调性和能量分辨率，第三条光束线将针对更高通量筛选进行优化。

项目成果

Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source.

在激光驱动的紧凑型同步加速器光源下使用 X 射线暗场成像进行肺气肿诊断。

• 发表时间: 2012-10-30
• 影响因子: 11.1
• 作者: Schleede, Simone;Meinel, Felix G;Bech, Martin;Herzen, Julia;Achterhold, Klaus;Potdevin, Guillaume;Malecki, Andreas;Adam;Thieme, Sven F;Bamberg, Fabian;Nikolaou, Konstantin;Bohla, Alexander;Yildirim, Ali O;Loewen, Roderick;Gif
• 通讯作者: Gif

Comparison of contrast-to-noise ratios of transmission and dark-field signal in grating-based X-ray imaging for healthy murine lung tissue.

健康小鼠肺组织基于光栅的 X 射线成像中透射和暗场信号的对比度与噪声比的比较。

• DOI: 10.1016/j.zemedi.2012.11.003
• 发表时间: 2013-09-01
• 期刊: Zeitschrift fur medizinische Physik
• 作者: F. Schwab;S. Schleede;D. Hahn;M. Bech;J. Herzen;S. Auweter;F. Bamberg;K. Achterhold;A. Yildirim;A. Bohla;O. Eickelberg;R. Loewen;M. Gifford;R. Ruth;M. Reiser;K. Nikolaou;F. Pfeiffer;F. Meinel
• 通讯作者: F. Meinel

Monochromatic computed tomography with a compact laser-driven X-ray source.

使用紧凑型激光驱动 X 射线源进行单色计算机断层扫描。

• 发表时间: 2013
• 影响因子: 4.6
• 作者: Achterhold, K;Bech, M;Schleede, S;Potdevin, G;Ruth, R;Loewen, R;Pfeiffer, F
• 通讯作者: Pfeiffer, F

X-ray Phase-Contrast Imaging at a Compact Laser-Driven Synchrotron Source

紧凑型激光驱动同步加速器源的 X 射线相衬成像

• 发表时间: 2024-09-14
• 期刊: Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment
• 影响因子: 1.4
• 作者: S. Schleede

Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source.

在紧凑型同步加速器光源下对乳房 X 线摄影模型进行多模态硬 X 射线成像。

• DOI: 10.1107/s0909049512017682
• 发表时间: 2012-07-01
• 期刊: Journal of synchrotron radiation
• 影响因子: 2.5
• 作者: S. Schleede;M. Bech;K. Achterhold;G. Potdevin;M. Gifford;R. Loewen;C. Limborg;R. Ruth;F. Pfeiffer
• 通讯作者: F. Pfeiffer