Enhanced Contrast Imaging for Screening of Early Pancreatic Cancer

增强对比成像筛查早期胰腺癌

基本信息

批准号：
7537923
负责人：
NICUSOR IFTIMIA
金额：
$ 15.2万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-11 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7537923
关键词：
Abdomen Acinar Cell Address Age Animal Model Animals Area Award Binding Biological Blood Circulation Cancer Etiology Cancer cell line Cancerous Capital Catheters Cell Line Cells Clinical Clinical Research Collaborations Computer software Condition Connective Tissue Data Data Set Depth Detection Development Diagnosis Diagnostic Diagnostic Neoplasm Staging Disease Ductal Ductal Epithelial Cell Ductal Epithelium Dyes Early Diagnosis Effectiveness Encapsulated Endocrine Endoscopy Engineering Epidermal Growth Factor Receptor Epithelial Equipment Evaluation Feasibility Studies Flour Fluorescence Fluorescent Dyes Frequencies Funding Gastrointestinal tract structure Gelatin Genes Goals Gold Government Growth Hand Hepatic Duct Histology Human Image Indocyanine Green Intravenous Invasive Label Lasers Lateral Lesion Light Local Therapy Localized Location Lung Lymphoid Tissue Malignant Neoplasms Malignant neoplasm of gastrointestinal tract Malignant neoplasm of pancreas Measurement Medical Surveillance Methods Modality Modeling Molecular Probes Morbidity - disease rate Morphology Nanotechnology Normal Cell Nude Mice Numbers Optical Coherence Tomography Optics Organ Organ Size Outcome Pancreas Pancreatic Ductal Adenocarcinoma Pancreatic duct Patients Peptides Personal Satisfaction Persons Peutz-Jeghers Syndrome Pharmaceutical Preparations Phase Probability Process Property Public Health Purpose Qualifying Reporting Research Research Personnel Resolution Scanning Screening for cancer Screening procedure Sensitivity and Specificity Signal Transduction Solutions Source Specificity Specimen Speed Staging Structure Surface Survival Rate Symptoms System Techniques Technology Testing Therapeutic Three-Dimensional Image Three-Dimensional Imaging Time Tissues Topical application Translating Ultrasonography United States United States Food and Drug Administration United States National Institutes of Health Universities Work base bile duct cancer cell cancer diagnosis cancer site chronic pancreatitis data acquisition design fluorescence imaging fluorophore imaging probe improved in vivo instrument instrumentation millimeter mortality mouse model nanoparticle neoplastic neoplastic cell optical imaging pancreatic neoplasm particle physical science programs size targeted delivery tomography tool tumor tumor xenograft

项目摘要

DESCRIPTION (provided by applicant): This proposal addresses a real need for an improved technology for early detection and rapid screening of ductal pancreatic cancer. Very recent advances in nanotechnology and high resolution optical coherence tomography (OCT) imaging have led to the development of new investigative tools capable of probing biological tissues at the cellular level. These tools can be used to localize abnormal neoplastic cells and expedite the cancer screening process. Physical Sciences Inc. (PSI), in collaboration with Northeastern University (NEU), proposes to develop a technology that could be used for screening of early stage epithelial cancerous lesions of the pancreatic duct. Endoscopically guided high-resolution OCT imaging, combined with fluorescence imaging, will be used to localize abnormal lesions within the tissue. Gold-coated gelatin-based particles, loaded with a fluorophore and functionalized to recognize the epidermal growth factor receptor (EGFR), will be topically or intravenously delivered to the body to target cancer cells, indicate cancer location, and enhance the contrast of OCT imaging. In Phase I, this technology will be tested on various pancreatic cancer cell lines in cultures and in an orthotropic mouse model of human pancreatic cancer. The Phase I results and observations will be used to improve this technology in a Phase II program. A pilot in vivo study on a large number of animals will be performed in Phase II to test the effectiveness of this technology for early stage ductal pancreatic cancer screening. PUBLIC HEALTH RELEVANCE: The proposed research could substantially improve cancer screening and surveillance, allowing for detection at an early stage when it is treatable and more easily curable. It is well established that earlier cancer diagnosis results in improved clinical outcomes, decreased morbidity, and reduced mortality from disease.

描述（由申请人提供）：该提案解决了对导管胰腺癌早期检测和快速筛查的改进技术的实际需求。纳米技术和高分辨率光学相干断层扫描 (OCT) 成像的最新进展促进了能够在细胞水平上探测生物组织的新研究工具的开发。这些工具可用于定位异常肿瘤细胞并加快癌症筛查过程。物理科学公司 (PSI) 与东北大学 (NEU) 合作，提议开发一种可用于筛查胰管早期上皮癌病变的技术。内窥镜引导下的高分辨率 OCT 成像与荧光成像相结合，将用于定位组织内的异常病变。载有荧光团并具有识别表皮生长因子受体 (EGFR) 功能的金涂层明胶颗粒将被局部或静脉注射到体内以靶向癌细胞、指示癌症位置并增强 OCT 成像的对比度。在第一阶段，该技术将在培养的各种胰腺癌细胞系和人类胰腺癌的正交异性小鼠模型中进行测试。第一阶段的结果和观察结果将用于在第二阶段项目中改进这项技术。第二阶段将对大量动物进行体内试点研究，以测试该技术用于早期导管胰腺癌筛查的有效性。公共健康相关性：拟议的研究可以大大改善癌症筛查和监测，从而可以在可治疗且更容易治愈的早期阶段进行检测。众所周知，早期癌症诊断可以改善临床结果、降低发病率并降低疾病死亡率。