North and Central Texas Clinical and Translational Science Initiative (KL2)

德克萨斯州北部和中部临床和转化科学计划 (KL2)

基本信息

批准号：
7497173
负责人：
Milton Packer
金额：
$ 148.83万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-17 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7497173
关键词：
Academia Address Adoption Advisory Committees Agreement Alabama Animals Aptitude Area Attention Award Awareness Bachelor&apos s Degree Basic Science Biochemistry Bioinformatics Biological Biological Markers Biology Biometry Biotechnology Caring Case Study Categories Cells Characteristics Chemicals Class Classification Clinic Clinical Clinical Investigator Clinical Research Clinical Research Protocols Clinical Sciences Clinical Trials Collaborations Collection Commit Communication Communities Community Health Complement 5a Complement component C1s Condition Conflict (Psychology)Consultations Critiques Daily Data Data Analyses Data Collection Data Quality Databases Dental Dentistry Depth Detection Development Diagnostic Dimensions Discipline Discipline of Nursing Disease Disease Progression Disputes Doctor of Medicine Doctor of Philosophy Doctor&apos s Degree Dose Drug Approval Drug Evaluation Drug Kinetics Education Educational Curriculum Educational Materials Educational process of instructing Educational workshop Elements Eligibility Determination End Point Engineered Gene Enrollment Ensure Environment Epidemiology Ethical Review Ethics Evaluation Evaluation Research Event Explosion Exposure to Extramural Activities Faculty Family Feedback Feeling Fees Fostering Foundations Functional disorder Funding Future Gene Cluster Gene Expression Gene Transfer Techniques Genetic Genetic Engineering Goals Grant Hand Health Health Promotion Hour Human Human Biology Image Immersion Investigative Technique Individual Industry Institution Institutional National Research Service Award Judgment Knowledge Laboratories Laboratory Finding Lead Leadership Learning Letters Life Literature Manuscripts Master&apos s Degree Measurement Measures Medical Medical Informatics Medical Students Medicine Mentored Clinical Scientist Development Program Mentors Mentorship Methodology Methods Minority Modeling Molecular Biology Techniques Molecular Epidemiology Molecular Genetics Molecular Medicine National Research Council Non-Citizen National Numbers Nursing Schools Office of the Director Ontology Outcome Paper Pathogenesis Patient Selection Patients Pediatrics Peer Group Peer Review Performance Personal Communication Pharmacologic Substance Pharmacology Pharmacy facility Phase Phase I Clinical Trials Phase II Clinical Trials Phase III Clinical Trials Physician Executives Physicians Physiological Physiology Play Policies Population Positioning Attribute Preparation Prevention Principal Investigator Problem Solving Procedures Process Protocols documentation Public Health Purpose Qualifying Range Recommendation Records Recruitment Activity Reporting Research Research Design Research Ethics Committees Research Institute Research Methodology Research Personnel Research Project Grants Research Proposals Research Training Resources Review Literature Risk Risk Factors Role Rotation SECTM1 gene Safety Sampling Schedule Scholarship Schools Science Scientist Side Social Sciences Specimen Standards of Weights and Measures Stress Stretching Structure Students Surrogate Endpoint System Talents Techniques Technology Testing Texas Therapeutic Therapeutic Intervention Thinking Time Training Training Programs Training and Education Transducers Translating Translational Research Translations United States Food and Drug Administration United States National Institutes of Health Universities Viral Vector Week Weight Wisconsin Work Writing administrative database base bench to bedside career clinically relevant college community based participatory research complement C4c complement C4d complement C5b concept cost data integration day design drug development expectation experience field study follow-up gene therapy human disease improved interest medical schools member multidisciplinary novel novel strategies novel therapeutics peer pre-doctoral professor programs prospective protocol development research clinical testing research study skills statistics success symposium theories tool uptake

项目摘要

We propose to establish a North and Central Texas Clinical and Translational Science Initiative (NCTCTSI), which will be led by the University of Texas Southwestern Medical School at Dallas and will include many of the nation's leading schools of allopathic and osteopathic medicine, dentistry, nursing, pharmacy, public health, engineering and computer science - which have already formed a highly functional relationship supported by a Roadmap K12 award. We have established a Department of Clinical Sciences, which is supported by faculty from all participating schools and which will serve as the academic home for our CTSA. The Department provides academic appointments to clinical and translational investigators together with faculty whose expertise and research is focused on methodological disciplines common to all clinical research - in order to promote multidisciplinary team building and problem solving. The NCTCTSI will build on existing nationally-recognized programs supported by K30, M01 and Roadmap K12 awards and will integrate numerous institutional strengths to offer 10 highly innovative and fully integrated key functions: (1) faculty recruitment, development and recognition; (2) research education, training and career development; (3) research plan development and support; (4) scientific review and investment; (5) regulatory knowledge and support; (6) participant and clinical interactions resources; (7) novel research methodology development; (8) translational technologies and resources; (9) biomedical informatics; and (10) community engagement. Particular strengths are: (1) the substantial and unequivocal commitment of participating institutions to the Initiative (which have pledged ~ $125 million to the NCTCTSI over the next five years); (2) an established academic and cultural home that currently address many of the goals of the NIH; (3) > 200 established clinical and translational investigators who will act as faculty and mentors; (4) a highly innovative approach to integrating key functions that will act to create bonds among the members of a multidisciplinary academic community; (5) a large and medically diverse patient base cared for by internationally-renowned hospitals (which are strong supporters of this initiative); (6) > $150 million in annual peer-reviewed grant support for clinical studies; (7) superb infrastructure to support clinical and translational research; and (8) program leadership with the time, experience and commitment to ensure the success of the Initiative. The coordinated synthesis of these strengths will allow the NCTCTSI to contribute to the national CTSA consortium and thus help to identify best practices that will benefit clinical and translational research throughout the nation.

我们建议在德克萨斯州北部和中部建立一个临床中心和转化科学计划（NCTCTSI），该计划将由德克萨斯大学领导达拉斯西南医学院将包括许多全国领先的医学院对抗疗法和整骨医学、牙科、护理、药学、公共卫生、工程和计算机科学——已经形成了由计算机科学支持的高度功能性的关系路线图 K12 奖。我们设立了临床科学系，并得到以下部门的支持：来自所有参与学校的教师，并将作为我们 CTSA 的学术之家。这部门为临床和转化研究人员提供学术任命其专业知识和研究重点是所有临床常见的方法论学科的教师研究——以促进多学科团队建设和问题解决。 NCTCTSI 将以 K30、M01 和路线图 K12 奖项支持的现有国家认可计划为基础并将整合众多机构优势，提供10个高度创新且完全集成的关键职能：（1）教师招聘、发展和表彰； (2) 研究教育、培训和职业发展； (3) 研究计划的制定和支持；（四）科学评审和投资； (5) 监管知识和支持； (6) 参与者和临床互动资源； (7)小说研究方法开发；（八）转化技术和资源； (9)生物医学信息学； (10) 社区参与。具体优势包括： (1) 实质性和参与机构对该倡议的明确承诺（已认捐约 1.25 亿美元）未来五年向 NCTCTSI 提交）； (2) 一个已建立的学术和文化家园，目前实现 NIH 的许多目标； (3) > 200 名成熟的临床和转化研究人员将担任教师和导师； (4) 高度创新的方法来整合将发挥作用的关键功能在多学科学术界的成员之间建立联系；（5）大而由国际知名医院（实力雄厚）提供医疗服务的多元化患者群体该倡议的支持者）； (6) > 每年为临床研究提供超过 1.5 亿美元的同行评审拨款支持； (7) 支持临床和转化研究的一流基础设施； (8) 项目领导确保该倡议成功的时间、经验和承诺。协调合成这些优势将使 NCTCTSI 能够为国家 CTSA 联盟做出贡献，从而帮助确定有利于全国临床和转化研究的最佳实践。