HUMAN MODELS OF SICKLE CELL VASCULAR DAMAGE

镰状细胞血管损伤的人体模型

• 批准号: 7716737
• 负责人: THOMAS Duane COATES
• 金额: $ 4.57万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716737
• 关键词: Blood; Blood Vessels; Blood flow; Computer Retrieval of Information on Scientific Projects Database; Depth; Dermal; Funding; Grant; Human; Hypoxia; Institution; Intervention; Lasers; Magnetic Resonance Imaging; Measures; Modeling; Oxygen; Research; Research Personnel; Resources; Sickle Cell; Sickle Cell Anemia; Source; Tissues; United States National Institutes of Health; capillary; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changes in dermal capillary blood flow and blood oxygen deliver to deep tissue in response to a brief period of hypoxia will be studied in normal controls and subjects with sickle cell anemia. These responses will be standardized so they can later be used to study pharmacological interventions that may improve blood flow and oxygen delivery. Blood oxygen level delivery will be measured by magnetic resonance imaging and dermal capillary blood flow will be measured using laser-Doppler flow.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 皮肤毛细血管血流和血氧的变化将在正常对照组和患有镰状细胞性贫血的受试者中响应短暂的缺氧而响应于深层组织。 这些反应将被标准化，以便以后可以用于研究可以改善血流和氧递送的药理干预措施。 血氧水平的递送将通过磁共振成像来测量，并使用激光多普勒流量测量真皮毛细血管血流。