Molecular Mechanisms of Basal Ganglia Regeneration in Songbirds

鸣禽基底神经节再生的分子机制

基本信息

批准号：
7473240
负责人：
Erich D Jarvis
金额：
$ 3.82万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-15 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7473240
关键词：
Academy Animals Area Basal Ganglia Behavior Behavioral Biochemistry Biological Neural Networks Birds Brain Bromodeoxyuridine Cell division Cells Collaborations Communication Computer software Corpus striatum structure Data FOS gene Genetic Grant Immediate-Early Genes Institutes Lesion Molecular Monitor Natural regeneration Neurons Pathway interactions Property Public Health Recovery Recovery of Function Recruitment Activity Research Role Science Slovakia Songbirds Speech Techniques Testing Time United States National Institutes of Health behavior change neurotoxic repaired sound vocal learning zebra finch

Academy Animals Area Basal Ganglia Behavior Behavioral Biochemistry Biological Neural Networks Birds Brain Bromodeoxyuridine Cell division Cells Collaborations Communication Computer software Corpus striatum structure Data FOS gene Genetic Grant Immediate-Early Genes Institutes Lesion Molecular Monitor Natural regeneration Neurons Pathway interactions Property Public Health Recovery Recovery of Function Recruitment Activity Research Role Science Slovakia Songbirds Speech Techniques Testing Time United States National Institutes of Health behavior change neurotoxic repaired sound vocal learning zebra finch

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项目摘要

DESCRIPTION (provided by applicant): While studying the role the basal ganglia pathway in learned vocal communication, we discovered an unexpected phenomenon: following neurotoxic lesions, the avian striatum recovered itself. This phenomenon, as far as we know, is unprecedented in the mammalian brain. Here we propose to investigate the mechanisms of this recovery: whether this is in fact new neuron regeneration or neuron invasion from the surrounding areas. Further we will determine the time course of this recovery accompanied with the behavioral (song) recovery. We will identify whether the cellular organization in the recovered striatum is the same as in intact striatum. Finally, we will test whether the recovery is specific to the neurotoxic lesion or if it is a more general aspect of the avian striatum. As the avian striatum contains neurons similar in their electrophysiological and molecular properties to their mammalian counterparts, the project is expected to impact our understanding of brain regeneration. The relevance of this research to public health is that we would find potential ways to repair damaged basal ganglia brain areas, and in particular for correcting speech deficits. This research will be done primarily in Slovakia at the Institute of Animal Biochemistry and Genetics at the Slovak Academy of Sciences in collaboration with Lubica Kubikova, as an extension of NIH grant #R01 DC007218-01.

描述（由申请人提供）：在研究基础神经节途径在学习的声音交流中的作用时，我们发现了一种意外的现象：遵循神经毒性病变，禽纹状体恢复了。据我们所知，这种现象在哺乳动物的大脑中是前所未有的。在这里，我们建议研究这种恢复的机制：这实际上是来自周围地区的新神经元再生还是神经元侵袭。此外，我们将确定此恢复的时间过程以及行为（歌曲）恢复。我们将确定回收纹状体中的细胞组织是否与完整纹状体相同。最后，我们将测试恢复是针对神经毒性病变的特定的还是它是禽纹状体的更一般方面。由于禽纹状体包含与哺乳动物对应物的电生理和分子特性相似的神经元，因此该项目有望影响我们对脑再生的理解。这项研究与公共卫生的相关性是，我们将找到修复受损的基底神经节脑区域的潜在方法，尤其是纠正语音缺陷的方法。这项研究将主要在斯洛伐克科学院动物生物化学和遗传学研究所的斯洛伐克进行，作为NIH授予＃R01 DC007218-01的扩展。