Oral Screening in India using Optical Imaging Technology

印度使用光学成像技术进行口腔筛查

• 批准号: 7463924
• 负责人: Ann M Gillenwater
• 金额: $ 5.92万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7463924
• 关键词: Algorithms; Aneuploidy; Appearance; Appendix; Area; Benign; Biological; Biological Markers; Biopsy; Breast; Cancer Center; Cancer Detection; Cancer Etiology; Cancer Patient; Cancerous; Carcinoma; Categories; Cessation of life; Clinical; Collaborations; Collagen; Communities; Country; Cytology; Data; Depth; Detection; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Disease; Dysplasia; Early Diagnosis; Early Intervention; Electronics; Enrollment; Environment; Epithelial; Epithelium; Evaluation; Excision; Faculty; Fiber Optics; Fluorescence; Funding; Genetic; Gold; Head and Neck Surgery; Health; Hemoglobin; Histologic; Histology; Histopathology; Hospitals; Human; Hyperkeratosis; Image; Imaging technology; India; Individual; Inflammation; Inflammatory; Institutes; International; Intervention; Invasive; Investigation; Keratin; Lateral; Lead; Lesion; Leukoplakia; Life; Light; Lighting; Localized; Loss of Heterozygosity; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Measures; Medical; Methodology; Microscope; Microscopic; Mitochondria; Molecular; Molecular Abnormality; Mouth Carcinoma; Mouth Neoplasms; Mucous Membrane; Neoplasms; Non-Invasive Cancer Detection; Optics; Oral; Oral Diagnosis; Oral Tobacco; Oral cavity; Oral mucous membrane structure; Organ; Outcome; Oxidation-Reduction; Patients; Pattern; Peripheral; Persons; Physicians; Pilot Projects; Population; Predictive Value; Premalignant; Property; Recruitment Activity; Relative (related person); Research Project Grants; Resolution; Resources; Risk; Sampling; Scientist; Screening for Oral Cancer; Screening for cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Site; Smoke; Source; Southeastern Asia; Spectrum Analysis; Staging; Standards of Weights and Measures; Survival Rate; System; Techniques; Technology; Testing; Texas; Time; Tissues; Tobacco; Tobacco Use Cessation; United States; United States National Institutes of Health; Variant; Videoconferences; Videoconferencing; Visit; Woman; Work; absorption; base; cancer diagnosis; carcinogenesis; chromophore; clinical Diagnosis; computerized data processing; cost; detector; digital; experience; functional outcomes; human subject; improved; malignant mouth neoplasm; mathematical model; member; men; mortality; mouth squamous cell carcinoma; neoplastic; new technology; optical imaging; oral dysplasia; oral lesion; oral surgery specialty; oral tissue; prospective; size; tool; transmission process; tumor; volunteer

DESCRIPTION (provided by applicant): Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. During carcinogenesis, the optical properties of tissue are altered and these changes can be used to non-invasively distinguish normal from neoplastic mucosa. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. Our first Aim is to determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will obtain wide-field autofluorescence and reflectance images of oral premalignant lesions (OPLs) in 90 patients who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India. These images will be compared to findings using standard white light (WL) illumination. At the same time, an in depth, focal interrogation from several sites using fluorescence and reflectance spectra will be performed. Clinical diagnoses using standard white light, clinical diagnoses using multispectral imaging, spectroscopy data, and cytology and histopathology diagnoses will be compared to determine the positive and negative predictive value of using the device. In Aim 2, we will determine whether this technology can improve screening and diagnosis in an Indian population with high risk for oral cancer but no clinically visible lesions using similar methodology. In Aim 3, we evaluate the correlation of presence of genetic damage (such as aneuploidy and loss of heterozygosity) and morphologic changes (hyperkeratosis, inflammation, dysplasia) to altered optical signatures. Successful completion of this project will determine the diagnostic potential and applicability of this technology for oral cancer detection and diagnosis in communities with limited resources. 7. Project Narrative Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. We will determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will compare optical data in 190 subjects who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India, to standard clinical diagnosis, histopathologic results, and molecular biomarker findings. Successful completion of this project will determine the diagnostic potential and applicability of this multispectral imaging and spectrsocpy technology for oral cancer detection and diagnosis in communities with limited resources.

描述（由申请人提供）：口腔癌是全球第六个最常见的癌症，三分之二的病例发生在发展中国家。在印度，它是男性中最常见的癌症，也是女性中第三大常见的癌症。只有一半的口腔癌患者生活了5年，甚至患有晚期疾病的患者的生存更少。早期检测和诊断的进步将大大提高生存率并减少口腔癌的痛苦。基于光学的诊断辅助工具正在有望改善上皮恶性肿瘤的发现。在致癌过程中，组织的光学特性会改变，这些变化可用于非侵入性区分正常与肿瘤粘膜。该国际协作项目的目标是基于先前的NIH资助工作，是确定新的光学成像技术，荧光和反射率成像和光谱法是否可以促进印度高风险人群中口腔肿瘤的早期发现和诊断。我们的第一个目的是确定印度高风险人群中潜在的恶性口腔病变的筛查和诊断是否可以改善筛查和诊断。我们将在孟买印度的塔塔纪念医院（Tata Memorial Hospital）招募90名患者的90名患者中，在90名患者中，我们将获得口腔前病变（OPL）的宽场自动荧光图像（OPL）。这些图像将与使用标准白光（WL）照明的发现进行比较。同时，将对使用荧光和反射光谱的多个位点进行深入的焦点询问。使用标准白光，使用多光谱成像，光谱数据以及细胞学和组织病理学诊断的临床诊断，以确定使用该设备的正和负预测值。在AIM 2中，我们将确定该技术是否可以改善口腔癌风险高的印度人群的筛查和诊断，但没有使用类似方法的临床可见病变。在AIM 3中，我们评估了遗传损伤（例如非整倍性和杂合性丧失）和形态学变化（高促病，炎症，发育不良）与光学特征改变的相关性。该项目的成功完成将确定该技术在资源有限的社区中对口腔癌检测和诊断的诊断潜力和适用性。 7。叙事叙事口腔癌是全球第六大癌症，三分之二以上发生在发展中国家。在印度，它是男性中最常见的癌症，也是女性中第三大常见的癌症。只有一半的口腔癌患者生活了5年，甚至患有晚期疾病的患者的生存更少。早期检测和诊断的进步将大大提高生存率并减少口腔癌的痛苦。基于光学的诊断辅助工具正在有望改善上皮恶性肿瘤的发现。该国际协作项目的目标是基于先前的NIH资助工作，是确定新的光学成像技术，荧光和反射率成像和光谱法是否可以促进印度高风险人群中口腔肿瘤的早期发现和诊断。我们将确定多光谱成像和光谱是否可以改善印度高风险人群中潜在恶性口腔病变的筛查和诊断。我们将在190名受试者中比较在孟买印度塔塔纪念医院进行口腔癌症筛查试验的190名受试者，与标准的临床诊断，组织病理学结果和分子生物标志物发现。该项目的成功完成将确定这种多光谱成像和光谱技术在资源有限的社区中对口腔癌检测和诊断的诊断潜力和适用性。