Drosophila Genomics Resource Center

果蝇基因组学资源中心

• 批准号: 7438381
• 负责人: JUSTEN R ANDREWS
• 金额: $ 40.25万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7438381
• 关键词: Address; Agriculture; Animal Genetics; Bioinformatics; Cell Line; Collection; Communities; Complementary DNA; Cultured Cells; DNA Microarray Chip; DNA Microarray format; Data; Development; Drosophila genus; Expressed Sequence Tags; Gene Expression; Genes; Genetic Models; Genomics; Goals; Homologous Gene; Indiana; Medical; Modeling; Operative Surgical Procedures; Purpose; Reagent; Regulation; Research; Resources; Slide; Study models; Techniques; Technology; Testing; Time; Universities; fly; functional genomics; genome sequencing; human disease; interest; vector

Drosophila is one of the outstanding models for studies of animal genetics, development, and regulation. As a genetic model, it has been characterized more fully than any other metazoan. At the same time, because of evolutionary conservation, Drosophila has tumed out to be an important model for fundamental studies of medical, agricultural, and biotechnological interest. Thus, it appears that >60% of human disease genes have Drosphila homologs. The completed Drosophila genome sequence, ongoing EST projects, and the increasing application of high-throughput genomics techniques by fly workers are paving the way for a comprehensive functional genomics of Drosophila. To reach this goal, the community requires ready, economical access to quality- assured genomics materials, and the current lack of such access is widely perceived as a serious roadblock. To address this need, we propose to create a Drosophila Genomics Resources Center (DGRC), hosted and operated by the Center for Genomics and Bioinformatics (CGB), Indiana University, Bloomington. The DGRC will consist of an Advisory Board and a Facility. The DGRC Advisory Board -- composed of genomics experts and community representatives -- will act as the Drosophila research community's agent, assessing needs and strategies and overseeing the operations of the DGRC Facility. The DGRC Facility will be located within the CGB. Its purpose will be to make research matedals for genomics more accessible to the Drosophila research community. Specifically, the DGRC Facility will: (1) Produce and distribute DNA microarray slides for gene expression analyses. (2) Collect and distribute other reagents and materials essential for Drosophila genomics research, including large clone sets, common transformation vectors, and cell lines. (3) Facilitate the collection and analysis of array expression data and promote the incorporation of results into the Gene Expression Omnibus (NCBI) and Flybase. (4) Test new and alternative genomics technologies as an aid to Advisory Board strategy decisions.

果蝇是研究动物遗传学，发育和调节的杰出模型之一。 作为遗传模型，它的表征比其他任何后生动物更全面。同时， 由于进化的保护，果蝇已成为基本的重要模型 医学，农业和生物技术兴趣的研究。因此，似乎有60％的人类疾病 基因具有荧光素同源物。 完成的果蝇基因组序列，正在进行的EST项目以及不断增加的应用 飞行工人的高通量基因组学技术正在为全面的功能铺平道路 果蝇的基因组学。为了实现这一目标，社区需要准备好，经济地获得质量 - 确保基因组学材料以及目前缺乏这种通道被广泛认为是严重的障碍。 为了满足这一需求，我们建议创建一个托管的果蝇基因组资源中心（DGRC） 并由布卢明顿印第安纳大学的基因组学和生物信息学中心（CGB）运营。这 DGRC将由顾问委员会和设施组成。 DGRC咨询委员会 - 由基因组学组成 专家和社区代表 - 将担任果蝇研究社区的代理人，评估 需求和策略，并监督DGRC设施的运营。 DGRC设施将位于 在CGB内。它的目的是使基因组学研究配合者更容易被 果蝇研究社区。 具体而言，DGRC设施将：（1）生产和分布基因的DNA微阵列载玻片 表达分析。 （2）收集和分发果蝇必不可少的试剂和材料 基因组学研究，包括大型克隆集，常见转化向量和细胞系。 （3）便利 阵列表达数据的收集和分析并促进结果纳入基因 表达综合（NCBI）和飞基。 （4）测试新的和替代基因组技术作为帮助 咨询委员会的策略决策。