DROSOPHILA GENOMICS RESOURCE CENTER

果蝇基因组资源中心

• 批准号: 7153975
• 负责人: JUSTEN R ANDREWS
• 金额: $ 89.76万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7153975
• 关键词: Drosophilidae; biomedical resource; biotechnology; cell line; functional /structural genomics; gene expression; genetic models; genetic registry /resource /referral center; microarray technology; molecular biology information system

DESCRIPTION (provided by applicant): Drosophila is one of the outstanding models for studies of animal genetics, development, and regulation. As a genetic model, it has been characterized more fully than any other metazoan. At the same time, because of evolutionary conservation, Drosophila has turned out to be an important model for fundamental studies of medical, agricultural, and biotechnological interest. Thus, it appears that greater than 60 percent of human disease genes have Drosphila homologs. The completed Drosophila genome sequence, ongoing EST projects, and the increasing application of high-throughput genomics techniques by fly workers are paving the way for a comprehensive functional genomics of Drosophila. To reach this goal, the community requires ready, economical access to quality assured genomics materials, and the current lack of such access is widely perceived as a serious roadblock. To address this need, we propose to create a Drosophila Genomics Resources Center (DGRC), hosted and operated by the Center for Genomics and Bioinformatics (CGB), Indiana University, Bloomington. The DGRC will consist of an Advisory Board and a Facility. The DGRC Advisory Board - composed of genomics experts and community representatives - will act as the Drosophila research community's agent, assessing needs and strategies and overseeing the operations of the DGRC Facility. The DGRC Facility will be located within the CGB. Its purpose will be to make research materials for genomics more accessible to the Drosophila research community. Specifically, the DGRC Facility will: (1) Produce and distribute DNA microarray slides for gene expression analyses. (2) Collect and distribute other reagents and materials essential for Drosophila genomics research, including large clone sets, common transformation vectors, and cell lines. (3) Facilitate the collection and analysis of array expression data and promote the incorporation of results into the Gene Expression Omnibus (NCBI) and Flybase. (4) Test new and alternative genomics technologies as an aid to Advisory Board strategy decisions.

描述（由申请人提供）： 果蝇是研究动物遗传学，发育和调节的杰出模型之一。作为遗传模型，它的表征比其他任何后生动物更全面。同时，由于进化保护，果蝇已成为医学，农业和生物技术兴趣基础研究的重要模型。因此，似乎超过60％的人类疾病基因具有荧光素同源物。 果蝇基因组序列，正在进行的EST项目以及飞行工人对高通量基因组技术的不断应用正在为果蝇的全面功能基因组学铺平道路。为了实现这一目标，社区需要准备好，经济的访问质量的保证基因组学材料，并且目前缺乏这种访问被广泛认为是严重的障碍。 为了满足这一需求，我们建议建立一个由布卢明顿印第安纳大学基因组学和生物信息学中心（CGB）托管和运营的果蝇基因组资源中心（DGRC）。 DGRC将由顾问委员会和设施组成。由基因组专家和社区代表组成的DGRC顾问委员会将充当果蝇研究社区的代理，评估需求和策略，并监督DGRC设施的运营。 DGRC设施将位于CGB内。其目的是使果蝇研究界更容易获得基因组学研究材料。 具体而言，DGRC设施将：（1）生产和分布DNA微阵列载玻片进行基因表达分析。 （2）收集和分发对果蝇基因组学研究所必需的其他试剂和材料，包括大型克隆集，常见转化载体和细胞系。 （3）促进阵列表达数据的收集和分析，并促进将结果纳入基因表达综合（NCBI）和Flybase中。 （4）测试新的和替代基因组技术作为咨询委员会战略决策的帮助。