Reliability of Cognitive ERPs in Children and Adults

儿童和成人认知 ERP 的可靠性

• 批准号: 7052018
• 负责人: PATRICIA L DAVIES
• 金额: $ 7.08万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052018
• 关键词: adolescence (12-20); age difference; attention; auditory discrimination; behavior test; bioimaging /biomedical imaging; brain electrical activity; brain mapping; clinical research; developmental neurobiology; electroencephalography; evoked potentials; executive function; human subject; middle childhood (6-11); young adult human (21-34)

DESCRIPTION (provided by applicant): The long-term goals of this program of research are to contribute to the increasing amount of evidence for continued development of the brain into early adulthood. Electroencephalographic (EEC) measures and neuropsychological assessments are being employed to investigate the interrelationships of maturation of specific brain regions and the development of cognitive and emotional processes in children and adolescents. The results obtained from this study will be applied to the development of a model that will elucidate interrelationships of variables representing stimulus-response mechanisms, trait, and state characteristics of an individual and their associated changes in various ERP measurements observed during periodic assessments in typically developing children using a longitudinal design. The goals of the proposed research are to: 1) Determine if developmental trends exist in the reliability of ERPs, and 2) Clarify the relationship of executive functions, specifically attention, to ERPs components and ERP reliability. The research design entails obtaining multiple channel EEC recordings from 30 participants in each of 3 age groups (8-yr olds, 12-yr olds and young adults) while performing 3 ERP paradigms: the novelty auditory oddball (an auditory discrimination task), contingent negative variation (a sustained attention task), and the error-related negativity (error-monitoring in simple visual discrimination task). Each participant will complete these EEG/ERP tasks in each of two visits separated by a 1-2 week period. Split-half and test-retest reliability coefficients will then be determined for the principle components of these ERP paradigms. Split-half and test-retest will then be recomputed using the standardized residuals instead of the original ERP measures. These new reliability coefficients are expected to be higher than those not accounting for variance due to waveform processing. Relationships of attentional measures and ERP reliability and the ERP components (i.e, CNV, P3a, P3b and ERN) will be evaluated. Health related impacts include understanding changes in the brain in relation to attention in childhood and adolescence. In addition, results have the potential of providing a wealth of information regarding individual differences in cognitive ERPs and ERP reliability. This information will be helpful, especially when clinical populations (e.g., attention deficit disorders and learning disabilities) are included in developmental ERP studies.

描述（由申请人提供）：该研究计划的长期目标是提供越来越多的证据，证明大脑持续发育到成年早期。脑电图（EEC）测量和神经心理学评估被用来研究儿童和青少年特定大脑区域成熟与认知和情感过程发展的相互关系。从这项研究中获得的结果将应用于开发一个模型，该模型将阐明代表个体刺激反应机制、特质和状态特征的变量之间的相互关系，以及在典型发育中的定期评估期间观察到的各种 ERP 测量值的相关变化。儿童使用纵向设计。拟议研究的目标是：1）确定 ERP 可靠性是否存在发展趋势，2）阐明执行功能（特别是关注）与 ERP 组件和 ERP 可靠性之间的关系。研究设计需要从 3 个年龄组（8 岁、12 岁和年轻人）各 30 名参与者获得多通道 EEC 录音，同时执行 3 种 ERP 范式：新颖的听觉怪异（听觉辨别任务）、偶然性负变化（持续注意力任务）和与错误相关的负性（简单视觉辨别任务中的错误监控）。每个参与者将在相隔 1-2 周的两次访问中完成这些 EEG/ERP 任务。然后将确定这些 ERP 范式的主要组成部分的分半和重测可靠性系数。然后，将使用标准化残差而不是原始 ERP 测量值重新计算分半和重测。这些新的可靠性系数预计将高于未考虑波形处理引起的方差的系数。将评估注意力测量和 ERP 可靠性以及 ERP 组件（即 CNV、P3a、P3b 和 ERN）的关系。与健康相关的影响包括了解与儿童期和青春期注意力相关的大脑变化。此外，结果有可能提供有关认知 ERP 和 ERP 可靠性个体差异的大量信息。这些信息将很有帮助，特别是当临床人群（例如，注意力缺陷障碍和学习障碍）被纳入发育 ERP 研究时。

项目成果

Test-Retest Reliability of Electroencephalographic Measures of Performance Monitoring in Children and Adults.

儿童和成人表现监测的脑电图测量的重测可靠性。

• 发表时间: 2020
• 影响因子: 1.5
• 作者: Lin, Mei;Davies, Patricia L;Stephens, Jaclyn;Gavin, William J
• 通讯作者: Gavin, William J

The Test-Retest Reliability of the Visually Evoked Contingent Negative Variation (CNV) in Children and Adults.

儿童和成人视觉诱发偶然负变异 (CNV) 的重测可靠性。

• 发表时间: 2016-04
• 影响因子: 1.5
• 作者: Taylor, Brittany K;Gavin, William J;Davies, Patricia L
• 通讯作者: Davies, Patricia L

Modeling the interrelationships between brain activity and trait attention measures to predict individual differences in reaction times in children during a Go/No-Go task.

对大脑活动和特质注意力测量之间的相互关系进行建模，以预测儿童在执行/不执行任务期间反应时间的个体差异。

• 发表时间: 2018-01-31
• 影响因子: 2.6
• 作者: Taylor, Brittany K;Gavin, William J;Grimm, Kevin J;Passantino, Deborah E;Davies, Patricia L
• 通讯作者: Davies, Patricia L

Towards a unified model of event-related potentials as phases of stimulus-to-response processing.

建立一个统一的事件相关电位模型作为刺激响应处理的阶段。

• 发表时间: 2019
• 影响因子: 2.6
• 作者: Taylor, Brittany K;Gavin, William J;Grimm, Kevin J;Prince, Mark A;Lin, Mei;Davies, Patricia L
• 通讯作者: Davies, Patricia L

Modeling electrophysiological measures of decision-making and performance monitoring in neurotypical children engaging in a speeded flanker task.

对参与快速侧翼任务的神经典型儿童的决策和表现监测的电生理测量进行建模。

• 发表时间: 2022-03
• 影响因子: 3.7
• 作者: Lin, Mei;Davies, Patricia L;Taylor, Brittany K;Prince, Mark A;Gavin, William J
• 通讯作者: Gavin, William J