COGNITIVE EVENT-RELATED POTENTIALS AND BRAIN MATURATION

认知事件相关潜力和大脑成熟

• 批准号: 2888726
• 负责人: PATRICIA L DAVIES
• 金额: $ 8.43万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-10 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2888726
• 关键词: adolescence (12-20); age difference; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; cognition; developmental neurobiology; electroencephalography; evoked potentials; human subject; middle childhood (6-11); neural information processing; performance; prefrontal lobe /cortex; young adult human (21-34)

The maturation of the frontal lobe of the brain may play an important role in the development of information processing abilities. Recordings of EEG and event-related potentials (ERPs) permit the examination of regional brain activity during the performance of specific information processing tasks. The goals of this research plan are: 1) to establish electrophysiological markers of development through adolescence; and 2) to relate the electrophysiological data to cognitive performance changes that occur in adolescence. This process will allow us to relate regional brain development as reflected in electrophysiological data to behavioral changes across ages. Three hypotheses are to be examined: 1) ERP patterns that are reflective of specific cognitive functioning will vary for participants of different ages; 2) ERPs associated with posterior regions of the brain will manifest adult properties at a younger age than ERPs associated with frontal regions of the brain; and 3) the ERP data will correlate with performance on behavioral tasks. These hypothesis will be tested by examining ERP components recorded while children and young adults perform specific information processing tasks. The educational objectives of this mentored research scientist award are: 1) The PI will expand research skills and extend research network. Dr. Sid Segalowitz will serve as mentor for this experience in the laboratory. The PI will attend courses that reinforce the laboratory experience. 2) Advance research wills of PI and develop new research projects addressing clinical intervention in rehabilitation. This will be accomplished through the completion of the research plan and the initiation of pilot studies that will examine ERP patterns in children with disabilities. 3) Promote skills in the dissemination of research results and laboratory management. The PI will prepare manuscripts for peer reviewed journals reporting the results of these studies and supervise graduate students in related research projects.

大脑额叶的成熟可能发挥重要作用 信息处理能力的发展。脑电图记录 和事件相关电位（ERP）允许检查区域 进行特定信息处理时的大脑活动 任务。本研究计划的目标是： 1) 建立 青春期发育的电生理标志物； 2) 至 将电生理数据与认知表现变化联系起来 发生在青春期。这个过程将使我们能够将区域大脑联系起来 电生理数据反映的行为发展 随年龄的变化。需要检验三个假设：1) ERP 模式 反映特定认知功能的信息会因情况而异 不同年龄段的参与者； 2）与后部区域相关的ERP 与 ERP 相比，大脑的部分功能会在更年轻​​的时候表现出成人的特性 与大脑额叶区域相关； 3) ERP 数据将 与行为任务的表现相关。这些假设将是 通过检查儿童和青少年时记录的 ERP 组件进行测试 成年人执行特定的信息处理任务。 该指导研究科学家奖的教育目标是： 1）PI将扩展研究技能并扩展研究网络。席德博士 Segalowitz 将担任实验室这段经历的导师。这 PI 将参加强化实验室经验的课程。 2） 推进 PI 的研究意愿并开发新的研究项目 临床康复干预。这将通过以下方式完成 完成研究计划并启动试点研究 它将检查残疾儿童的 ERP 模式。 3）推广 传播研究成果和实验室管理的技能。 PI 将为报告同行评审的期刊准备手稿 这些研究的结果并监督相关的研究生 研究项目。