fMRI and Ghrelin in Obesity and Binge Eating Disorder

fMRI 和 Ghrelin 在肥胖和暴食症中的作用

• 批准号: 7106137
• 负责人: ALLAN GELIEBTER
• 金额: $ 16.14万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106137
• 关键词: appetite; behavior test; behavioral /social science research tag; binge eating disorder; blood chemistry; body composition; brain imaging /visualization /scanning; circadian rhythms; clinical research; diet route /schedule; functional magnetic resonance imaging; ghrelin; hormone regulation /control mechanism; human subject; interview; longitudinal human study; mental disorder diagnosis; mood disorders; obesity; patient oriented research; prefrontal lobe /cortex; questionnaires; stimulus /response; time resolved data

DESCRIPTION (provided by applicant): The prevalence of obesity continues to increase in the US and globally. Obesity results in increased morbidity and mortality, especially from diabetes and heart disease. Approximately 30% of obese individuals seeking treatment have binge eating disorder (BED). They ingest very large meals without purging afterwards as in bulimia nervosa. BED, the most common characterized eating disorder, causes much distress and contributes to the development of obesity. Although psychological factors have been studied, little is known about the biological factors of BED. This clinical research study will focus on brain imaging and gut hormones following a meal to examine differences between BED and non-BED subjects. There will be 24 obese BED (12 m, 12 f) and 24 weight-matched obese non-BED (12 m, 12 f) subjects. On one day, a fixed liquid meal (750 ml) will be ingested and blood drawn to measure various appetite hormones including ghrelin, PYY, and GLP-1, measured before and during a 2-hour period afterwards. The prediction is a lower fasting level of ghrelin and a smaller postprandial fall in BED compared to non-BED subjects. Also predicted are lower fasting levels and smaller postprandial increases of PYY and GLP-1 in BED compared to non-BED subjects. On another day, only water (750 ml) will be ingested as a control for diurnal variation in these hormones. At 135 min after the fixed meal or water, functional imaging (fMRI) will be employed to examine brain activation areas in response to visual and auditory stimuli of binge foods, nonbinge foods, and nonfoods. Greater activation is expected in such areas as the prefrontal cortex in response to binge foods relative to the other stimuli groups in BED than in nonBED subjects. Increased activation is also expected to binge food stimuli in the BED subjects even in the fed state as binge eating often occurs in the absence of hunger. On a third day, various psychological scales to assess eating behavior and mood will be administered. Body composition will be measured to obtain percentage body fat to verify similar body composition in the two groups. This study on brain imaging and meal-related appetite hormones should improve our knowledge of the underlying biological factors in Binge Eating Disorder (BED). This may lead to improved diagnosis and treatments to help restore normal appetite hormone levels and brain activity in BED, a disorder which is increasing in prevalence alongside obesity.

描述（由申请人提供）：在美国和全球范围内，肥胖症的患病率持续增加。肥胖会导致发病率和死亡率增加，尤其是糖尿病和心脏病。大约 30% 寻求治疗的肥胖者患有暴食症 (BED)。他们吃下大量的食物，但之后却没有像神经性贪食症那样进行净化。暴饮暴食是最常见的饮食失调症，会引起很多痛苦并导致肥胖的发生。尽管心理因素已被研究，但对于暴食症的生物学因素却知之甚少。这项临床研究将重点关注餐后大脑成像和肠道激素，以检查暴食症和非暴食症受试者之间的差异。将有 24 名肥胖 BED（12 m，12 f）和 24 名体重匹配的肥胖非 BED（12 m，12 f）受试者。有一天，将摄入固定的流食（750 毫升）并抽血来测量各种食欲激素，包括 ghrelin、PYY 和 GLP-1，在之前和之后 2 小时内进行测量。预测结果是，与非暴食者相比，空腹饥饿素水平较低，餐后暴食率下降幅度较小。还预测，与非暴食者相比，暴食者的 PYY 和 GLP-1 的空腹水平较低，餐后增加较小。另一天，仅摄入水（750 毫升）作为这些激素昼夜变化的对照。在固定膳食或水后 135 分钟，将采用功能成像 (fMRI) 检查大脑激活区域，以响应暴食、非暴食和非食物的视觉和听觉刺激。与非暴饮暴食者相比，暴饮暴食者的前额皮质等区域相对于其他刺激组的反应预计会更加活跃。即使在进食状态下，增加的激活也会导致暴食症受试者暴食食物刺激，因为暴食经常发生在没有饥饿的情况下。第三天，将进行各种心理量表来评估饮食行为和情绪。将测量身体成分以获得体脂百分比，以验证两组的相似身体成分。这项关于大脑成像和与膳食相关的食欲激素的研究应该会提高我们对暴食症（BED）潜在生物学因素的了解。这可能会改进诊断和治疗方法，帮助恢复暴食症的正常食欲激素水平和大脑活动，暴食症是一种与肥胖一起流行的疾病。