Ethanol and Social Interactions in Adolescent Rats

乙醇与青春期大鼠的社会互动

• 批准号: 7008901
• 负责人: ELENA I VARLINSKAYA
• 金额: $ 22.04万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008901
• 关键词: adrenocorticotropic hormone; age difference; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; corticosterone; drug tolerance; ethanol; juvenile animal; laboratory rat; motivation; neuropsychology; social behavior; socioenvironment; substance abuse related behavior

DESCRIPTION (provided by applicant): First experiences with alcohol in humans occur predominantly in adolescence, and drinking in a context of social interactions appears to be a virtually universal situation. Attractiveness of ethanol at this age is predominantly based on its properties to produce social facilitation and alleviate anxiety, since a high significance of social interactions, high social motivation and high frequency of anxiogenic situations characterize adolescence as a developmental period. Age-specific neural alterations also make adolescents notably hyposensitive to a number of the effects of ethanol. Therefore, the high risk of extensive alcohol use in adolescence is determined by a unique combination of social, motivational, environmental and neurobehavioral factors. Given that certain behavioral features, including age-related increase in social behavior, are common among adolescents of different mammalian species, peer-directed social activity of adolescent rats appears to have promise as an experimental model for the study of adolescent responsiveness to ethanol. The present proposal is to investigate how social and environmental factors contribute to responsiveness to ethanol in adolescence. Specifically, the proposed experiments will explore acute effects of ethanol on different forms of social behavior and social motivation in familiar and unfamiliar (anxiogenic) environments. Testing in a familiar environment will assess age-related differences in sensitivity of social behavior to activating and suppressing effects of ethanol, whereas testing in an unfamiliar environment will provide information about age-related differences in sensitivity to the anxiolytic effects of ethanol. Given that responsiveness to ethanol can be modified dramatically by repeated administrations, and that the emergence of these adaptations may also vary with age, the proposed experiments will investigate age-related peculiarities in the development of chronic tolerance to inhibitory effects of ethanol on social behavior as well as to its anxiolytic effects. Comparison of ethanol effects in weanling, adolescent and adult rats will allow us to outline peculiarities of adolescent responding to ethanol that may be unique to adolescence as a developmental period.

描述（由申请人提供）：人类首次饮酒经历 主要发生在青少年时期，并且在社交场合饮酒 互动似乎是一种几乎普遍的情况。的吸引力 这个时代的乙醇主要基于其生产社会的特性 促进和缓解焦虑，因为社交具有重要意义 互动、高社会动机和高致焦虑频率 情况将青春期描述为一个发展时期。特定年龄 神经改变也使青少年对许多 乙醇的影响。因此，大量饮酒的风险很高 青春期是由社会、动机、 环境和神经行为因素。鉴于某些行为 特征，包括与年龄相关的社会行为的增加，在 不同哺乳动物物种的青少年，同伴指导的社会活动 青春期大鼠似乎有希望作为该研究的实验模型 青少年对乙醇的反应。目前的建议是调查 社会和环境因素如何影响对乙醇的反应 青春期。具体来说，拟议的实验将探索急性影响 乙醇对不同形式的社会行为和社会动机的影响 熟悉和不熟悉的（致焦虑的）环境。在熟悉的环境中进行测试 环境将评估与年龄相关的社会敏感性差异 行为激活和抑制乙醇的作用，而测试 陌生的环境会提供与年龄相关的信息 对乙醇抗焦虑作用的敏感性差异。鉴于 通过重复可以显着改变对乙醇的反应 主管部门，并且这些适应的出现也可能随 年龄，拟议的实验将调查与年龄相关的特征 对乙醇对社会的抑制作用产生慢性耐受性 行为及其抗焦虑作用。乙醇效果比较 断奶、青少年和成年大鼠将使我们能够概述 青少年对乙醇的反应可能是青春期所特有的 发育期。