Neural recruitment during self-control of smoking: An fMRI paradigm

吸烟自我控制过程中的神经募集：功能磁共振成像范式

• 批准号: 7318115
• 负责人: John R Monterosso
• 金额: $ 34.65万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318115
• 关键词: Abstinence; Addictive Behavior; Anterior; Area; Attention; Basic Science; Behavior; Behavioral; Behavioral inhibition; Biological Neural Networks; Boxing; Brain; Brain region; Breathing; Characteristics; Cigarette; Cigarette Smoker; Clinical; Data; Decision Making; Dorsal; Drug usage; Effectiveness; Environment; Equipment and supply inventories; Functional Magnetic Resonance Imaging; Gambling; Goals; IFNG gene; Image; Image Analysis; Impulsivity; Individual Differences; Inferior frontal gyrus; Iowa; Laboratories; Magnetic Resonance Imaging; Maintenance; Masks; Measures; Methodology; Methods; Modeling; Motor; Nicotine; Numbers; Participant; Patient Self-Report; Performance; Personality; Pharmaceutical Preparations; Prefrontal Cortex; Procedures; Process; Property; Psychometrics; Recruitment Activity; Reporting; Research Personnel; Resolution; Resources; Rewards; Scanning; Score; Self-control as a personality trait; Short-Term Memory; Side; Signal Transduction; Smoke; Smoking; Specific qualifier value; Speed; Standards of Weights and Measures; Substance Addiction; System; Task Performances; Techniques; Testing; Therapeutic Intervention; Week; Work; addiction; base; behavior measurement; behavior test; blood oxygen level dependent; cigarette smoking; cingulate cortex; clinical Diagnosis; clinical application; craving; day; drug of abuse; follow-up; independent component analysis; indexing; insight; neural recruitment; programs; relating to nervous system; response; smoke inhalation; theories; trait; Abstinence; Addictive Behavior; Anterior; Area; Attention; Basic Science; Behavior; Behavioral; Behavioral inhibition; Biological Neural Networks; Boxing; Brain; Brain region; Breathing; Characteristics; Cigarette; Cigarette Smoker; Clinical; Data; Decision Making; Dorsal; Drug usage; Effectiveness; Environment; Equipment and supply inventories; Functional Magnetic Resonance Imaging; Gambling; Goals; IFNG gene; Image; Image Analysis; Impulsivity; Individual Differences; Inferior frontal gyrus; Iowa; Laboratories; Magnetic Resonance Imaging; Maintenance; Masks; Measures; Methodology; Methods; Modeling; Motor; Nicotine; Numbers; Participant; Patient Self-Report; Performance; Personality; Pharmaceutical Preparations; Prefrontal Cortex; Procedures; Process; Property; Psychometrics; Recruitment Activity; Reporting; Research Personnel; Resolution; Resources; Rewards; Scanning; Score; Self-control as a personality trait; Short-Term Memory; Side; Signal Transduction; Smoke; Smoking; Specific qualifier value; Speed; Standards of Weights and Measures; Substance Addiction; System; Task Performances; Techniques; Testing; Therapeutic Intervention; Week; Work; addiction; base; behavior measurement; behavior test; blood oxygen level dependent; cigarette smoking; cingulate cortex; clinical Diagnosis; clinical application; craving; day; drug of abuse; follow-up; independent component analysis; indexing; insight; neural recruitment; programs; relating to nervous system; response; smoke inhalation; theories; trait

DESCRIPTION (provided by applicant): Appetitive processes (e.g., reward-seeking and some aspects of craving) represent only one side of addiction; failed attempts to exert "self-control" over one's drug use are built-in to the clinical diagnosis of substance dependence. Attempts to study brain substrates of self-control have generally relied on laboratory models, such as decision-making tasks (e.g., the Iowa Gambling Task) and speeded tests of inhibitory control (e.g., the Go/No-Go Task) that have uncertain relevance to abstaining from drug use. We propose to identify substrates of self-control more directly using functional Magnetic Resonance Imaging (fMRI) in conjunction with a specialized apparatus that allows cigarette smoke inhalation in the scanning environment. Fifty cigarette smokers (abstinent 12 h) will complete a "Smoking Self-Control Challenge" that has been developed through successful pilot work. The task includes two types of 20-sec trials: "Smoke Unavailable" trials in which participants are signaled that a valve allowing cigarette smoke inhalation is closed, and "Smoke Available" trials, in which smoke is immediately available, but participants are encouraged to "try not to smoke on as many of these rounds as you can manage". The primary functional measure will be the difference in fMRI signal between Smoke Available trials in which the participant abstains, and trials in which smoke was not available ("Voluntary Abstinence" - "Smoke Unavailable"). Craving will be measured on every trial (by button presses) to allow for its covariation, as well as to allow assessment of its potential moderating effect on neural activity during voluntary abstinence. The fMRI task will be given during two sessions separated by approximately two weeks. Based on preliminary data, we anticipate that voluntary abstinence will be associated with increased neural activity in the right ventrolateral and dorsolateral prefrontal cortex as well as in the dorsal anterior cingulate cortex and supplementary motor area. Standard psychometric techniques will be applied to assess the reliability and short-term stability of performance and of fMRI signal change during the task. Two additional days of behavioral testing will allow performance on the task to be related to established measures of decision-making, inhibitory control, and personality. The proposed method will allow imaging studies of neural systems underlying self-control, complimenting existing imaging methods used to study craving for cigarettes and drugs of abuse. With the primary procedures already operational and in use, this 2-year project should yield valuable insights into the substrates of self-control, with both basic science and clinical implications.

描述（由申请人提供）：食用过程（例如，寻求奖励和渴望的某些方面）仅代表成瘾的一方；对使用药物使用的“自我控制”的尝试失败，是对物质依赖性的临床诊断。研究自我控制的大脑基板的尝试通常依赖于实验室模型，例如决策任务（例如爱荷华州赌博任务）和抑制性控制的加快测试（例如，GO/NO-NO-GO任务）与免除药物使用不确定的相关性。我们建议使用功能磁共振成像（fMRI）与专门的设备一起使用功能磁共振成像（fMRI）更直接地识别自我控制的底物，该设备允许在扫描环境中吸入香烟烟雾。五十名吸烟者（戒烟12小时）将完成通过成功的飞行员工作开发的“吸烟自我控制挑战”。该任务包括两种类型的20-SEC试验：“烟雾不可用”试验，其中参与者表示允许允许香烟烟雾吸入烟雾吸入的阀门，并立即进行“烟雾”试验，但鼓励参与者尝试不要在这些回合中尽可能多地进行烟雾。”主要的功能措施将是参与者戒烟的烟雾可用试验之间的fMRI信号的差异，以及不可用的烟雾的试验（“自愿禁欲” - “烟雾不可用”）。渴望将在每次试验（按按钮按下）中进行衡量，以允许其协调，并允许评估其在自愿戒酒期间对神经活动的潜在调节作用。 FMRI任务将在大约两周间分开的两个会议期间给出。根据初步数据，我们预计自愿节制将与右侧外侧和背外侧前额叶皮层以及背扣带回皮层和补充运动区的神经活动增加有关。标准心理测量技术将用于评估任务过程中性能和fMRI信号变化的可靠性和短期稳定性。另外两天的行为测试将使该任务的绩效与既定的决策，抑制性控制和人格的措施有关。所提出的方法将允许对自我控制的基础神经系统进行成像研究，以称赞用于研究渴望香烟和滥用药物的现有成像方法。借助已经运行和使用的主要程序，这项为期两年的项目应具有基础科学和临床意义的自我控制底物的宝贵见解。