Acute effects of sweet flavoring and nicotine in e-cigarettes on brain activity during food decisions
电子烟中甜味剂和尼古丁对食物决策过程中大脑活动的急性影响
基本信息
- 批准号:10598091
- 负责人:
- 金额:$ 20.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAcuteAmericanAppetite RegulationBehaviorBehavioralBerryBindingBody WeightBody mass indexBrainBrain regionCherry - dietaryCigaretteCigarette SmokerClinicalConsumptionCouplingCuesDatabasesDesire for foodElectronic cigaretteEnrollmentFlavoringFoodFunctional Magnetic Resonance ImagingGlucoseGoalsHomeostasisHumanHungerHypothalamic structureImageLinkMaintenanceMeasuresMedialMetabolicMetabolismNeurosciencesNicotineNicotine WithdrawalNutrientObesityOralOverweightParticipantPerfusionPersonsPlayPopulationProtocols documentationPublic HealthReportingResearchResolutionRestRoleRunningSatiationSavoryScanningSensorySignal TransductionStandardizationSweetening AgentsTaste PerceptionTestingVentral StriatumVisitVisualWeightWeight GainWeight maintenance regimenWorkarterial spin labelingattenuationbehavior measurementbiobehaviorblood oxygen level dependentcigarette smokecigarette smokingdesignelectronic cigarette useelectronic cigarette userelectronic liquidexperiencefood flavorincreased appetiteindexinginterestliquid formulationneuralneuroimagingnon-smokerpublic health interventionreceptorrecruitresponsesmoking cessationstructural imagingsweet taste perceptiontobacco flavortoolvapingyoung adult
项目摘要
PROJECT SUMMARY
Use of e-cigarettes has become widespread in young adults. One factor motivating initiation and maintenance
of e-cigarette use is its perceived value in weight management. This is especially true among those with
overweight and obesity. However, the actual effects of e-cigarette use on appetite are not well characterized.
In the proposed work we will examine the impact of two common e-liquid constituents that may be relevant: 1)
sweet flavoring, and 2) nicotine content. Through THE USC-TCORS database of active research participants,
we will enroll thirty-two young adult daily e-cigarette users with BMI in the overweight or obese range.
Participants will complete a baseline session followed by four neuroimaging test-sessions, each after overnight
fast and abstinence from any nicotine products. At each neuroimaging session, participants will complete a 30-
min vaping protocol prior to testing. The content of the e-liquid for sessions will vary according to a 2 X 2
design varying flavor (Sweet+/Sweet-) and nicotine content (Nic+/Nic-), Subsequent to vaping, participants will
undergo functional Magnetic Resonance Imaging (fMRI). During imaging participants will complete a task in
which they have the opportunity to bid real money on available food (half sweet and half savory), with the
possibility of consumption immediately following scanning (Food Bid Task). In past use of this task, we have
shown reduction in monetary bids and in MR-signal (a marker of neural activity) within brain regions linked to
appetite following oral consumption of non-nutritive sweetener (sweet taste without nutrients). Based primarily
on past work with cigarette smoke, we anticipate that nicotine will be associated with attenuation of activity
within brain regions linked to appetite during food decisions, and with reduced monetary bids. Possible effects
of sweet flavor are less clear, since both sensory-specific satiety (attenuation of appetite for similarly flavored
foods) and sensory-specific appetite (increased appetite for similarly flavored foods) have been reported when
aroma and taste is experienced without consumption. Participants will also complete a resting state scan using
Arterial Spin Labeling (ASL) to quantify any general effects of study variables on perfusion throughout the
brain. The proposed work leverages the multiple PIs expertise in e-cigarette use (Tackett), CNS regulation of
appetite (Page) and decision neuroscience (Monterosso). Findings will provide essential information for
understanding the connection between e-cigarette use and appetite.
项目概要
电子烟的使用在年轻人中已变得普遍。激励启动和维护的一个因素
电子烟使用的关键在于其在体重管理方面的感知价值。对于那些患有以下疾病的人来说尤其如此
超重和肥胖。然而,电子烟的使用对食欲的实际影响尚不清楚。
在拟议的工作中,我们将研究两种可能相关的常见电子烟液成分的影响:1)
甜味剂,2) 尼古丁含量。通过活跃研究参与者的 USC-TCORS 数据库,
我们将招募 32 名 BMI 在超重或肥胖范围内的每日使用电子烟的年轻成人。
参与者将完成一个基线会话,然后进行四次神经影像测试,每次都在过夜后进行
快速戒除任何尼古丁产品。在每次神经影像学会议上,参与者将完成 30-
测试前的最小电子烟协议。会话的电子液体的内容将根据 2 X 2
设计不同的口味(Sweet+/Sweet-)和尼古丁含量(Nic+/Nic-),在吸电子烟后,参与者将
接受功能性磁共振成像 (fMRI)。在成像过程中,参与者将完成一项任务
他们有机会用真钱购买可用的食物(一半甜一半咸),
扫描后立即消费的可能性(食品投标任务)。在过去使用此任务时,我们有
显示出与以下相关的大脑区域内的货币出价和 MR 信号(神经活动标记)的减少
口服非营养性甜味剂(没有营养的甜味)后的食欲。主要基于
根据过去对香烟烟雾的研究,我们预计尼古丁将与活性减弱有关
在做出食物决定时与食欲相关的大脑区域内,并减少货币出价。可能的影响
甜味的味道不太清楚,因为感官特定的饱腹感(对类似味道的食欲减弱)
据报道,当
无需食用即可体验香气和味道。参与者还将使用以下方法完成静息状态扫描
动脉旋转标记 (ASL),用于量化研究变量对整个灌注过程的一般影响
脑。拟议的工作利用了电子烟使用(Tackett)、CNS 监管等方面的多个 PI 专业知识
食欲(佩奇)和决策神经科学(蒙特罗索)。调查结果将为以下人员提供重要信息:
了解电子烟的使用与食欲之间的联系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John R Monterosso其他文献
John R Monterosso的其他文献
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{{ truncateString('John R Monterosso', 18)}}的其他基金
Acute effects of sweet flavoring and nicotine in e-cigarettes on brain activity during food decisions
电子烟中甜味剂和尼古丁对食物决策过程中大脑活动的急性影响
- 批准号:
10438421 - 财政年份:2022
- 资助金额:
$ 20.63万 - 项目类别:
Neuroeconomics of sugars: Glucose vs. fructose effects on reward signaling
糖的神经经济学:葡萄糖与果糖对奖励信号的影响
- 批准号:
9321514 - 财政年份:2017
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7658304 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7828210 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Effect of anticipated delay on neural response to signal of future reward
预期延迟对未来奖励信号的神经反应的影响
- 批准号:
7473092 - 财政年份:2008
- 资助金额:
$ 20.63万 - 项目类别:
Neural recruitment during self-control of smoking: An fMRI paradigm
吸烟自我控制过程中的神经募集:功能磁共振成像范式
- 批准号:
7318115 - 财政年份:2007
- 资助金额:
$ 20.63万 - 项目类别:
Neural recruitment during self-control of smoking: An fMRI paradigm
吸烟自我控制过程中的神经募集:功能磁共振成像范式
- 批准号:
7487077 - 财政年份:2007
- 资助金额:
$ 20.63万 - 项目类别:
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