SPECIFIC CHEMICAL INTERACTIONS IN MATRIX-INCORPORATED INSULIN STRUCTURES

基质结合的胰岛素结构中的特定化学相互作用

• 批准号: 7369520
• 负责人: JUN WANG
• 金额: $ 0.02万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369520
• 关键词: SPECIFIC; CHEMICAL; INTERACTIONS; MATRIX; INCORPORATED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been a powerful technique in the bio-macromolecules field. The matrix, a small organic molecule, plays a key role in the mass spectral method. The MALDI method has been developed empirically and its mechanism is not yet fully understood. The motivation of this project is to understand how the matrix molecule works or how it interacts with the protein. The aim of this work is to find specific interactions between the protein and the matrix molecule, so it will help explain the formation of a protein cation and how the proton transfer occurs.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。基质辅助激光解吸/电离质谱法（MALDI-MS）在生物大分子领域一直是一种强大的技术。矩阵是一种小的有机分子，在质谱法中起关键作用。 MALDI方法已经从经验上开发出来，其机制尚未完全理解。该项目的动机是了解基质分子如何工作或与蛋白质相互作用。这项工作的目的是找到蛋白质与基质分子之间的特定相互作用，因此它将有助于解释蛋白质阳离子的形成以及质子转移的发生方式。