7.0T/210 Imaging System

7.0T/210成像系统

• 批准号: 6877522
• 负责人: Brian D. Ross
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877522
• 关键词: Mammalia; bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging; whole body imaging /scanning

DESCRIPTION (provided by applicant): The purpose of this application is to locate a state-of-the-art actively shielded 7.0T/210mm bore MR] system at the University of Michigan Center for Molecular Imaging (CMI) for small animal MR imaging and spectroscopy. The CMI is poised to move into a new facility at the end of 2005 as the current 50 year old facility is beyond its lifespan. The CMI functions as an essential component for a comprehensive research program in Molecular Imaging and Small Animal Imaging at the University of Michigan. The new facility will provide a centralized resource for pre-clinical imaging which includes anatomical and functional imaging, as well as development of novel reporter molecules of specific molecular and biological processes. Reconfiguration of the facility to operate within the vivarium of a new research building will allow biomedical researchers access to imaging without compromise to the pathogen-free status of their animal models. This unique combination of resources will assure continued productivity in CMI-supported programs. To date, the CMI has served over 50 researchers across 24 Departments and 6 Schools. Scientific aims of this multidisciplinary group address major health issues including cancer, pathologies of the CNS and cardiovascular disease. The requested replacement of our current 7 Tesla MR system is required as its magnet design (non-shielded) can not be accommodated in the new space due to it magnetic fringe field being too large. Moreover, the console attached to the old magnet is a hybrid containing parts as dated as 1991. The new system will serve the needs of five Nit-I-funded investigators. The CMI, with its in-house staff of twenty five investigators and support staff has the expertise in small animal imaging to support the shared instrument and its users. The proposed 7 Tesla MRI system will have a Varian Associates, Inc. INOVA console and a Magnex Scientific, Inc. actively shielded superconducting magnet with 40 G/cm shielded gradients. Overall, this MRI system will provide state-of-the-art performance and capability for imaging of small animal models of human diseases. This proposal provides documentation of our need, past contributions to small animal imaging, organizational and training competence, and institutional commitment.

描述（由申请人提供）： 此应用的目的是在密歇根大学分子成像中心 (CMI) 找到最先进的主动屏蔽 7.0T/210mm 孔径 MR] 系统，用于小动物 MR 成像和光谱学。 CMI 准备于 2005 年底迁入新设施，因为目前已有 50 年历史的设施已超出其使用寿命。 CMI 是密歇根大学分子成像和小动物成像综合研究项目的重要组成部分。新设施将为临床前成像提供集中资源，包括解剖和功能成像，以及特定分子和生物过程的新型报告分子的开发。重新配置该设施以在新研究大楼的动物饲养场内运行，将使生物医学研究人员能够在不影响动物模型无病原体状态的情况下进行成像。这种独特的资源组合将确保 CMI 支持的项目持续保持生产力。迄今为止，CMI 已为 24 个系和 6 个学院的 50 多名研究人员提供服务。 这个多学科小组的科学目标是解决重大健康问题，包括癌症、中枢神经系统病理和心血管疾病。我们要求更换当前的 7 Tesla MR 系统，因为其磁体设计（非屏蔽）由于磁边缘场太大而无法容纳在新空间中。此外，连接到旧磁铁上的控制台是一个混合体，包含 1991 年的部件。新系统将满足五名 Nit-I 资助的调查员的需求。 CMI 拥有由 25 名研究人员和支持人员组成的内部员工，拥有小动物成像方面的专业知识，可以为共享仪器及其用户提供支持。拟议的 7 Tesla MRI 系统将配备 Varian Associates, Inc. INOVA 控制台和 Magnex Scientific, Inc. 具有 40 G/cm 屏蔽梯度的主动屏蔽超导磁体。总体而言，该 MRI 系统将为人类疾病小动物模型的成像提供最先进的性能和能力。该提案提供了我们的需求、过去对小动物成像的贡献、组织和培训能力以及机构承诺的记录。