IL-12 GENE THERAPY TO PRIME AND REPOLARIZE ANTI-TUMOR TH1-TYPE T CELLS

IL-12 基因疗法启动并重新极化抗肿瘤 TH1 型 T 细胞

• 批准号: 7596852
• 负责人: Walter J. Storkus
• 金额: $ 21.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7596852
• 关键词: Animals; Antigens; Apoptotic; Biological Assay; Brain; Brain Neoplasms; CD4 Positive T Lymphocytes; CD8B1 gene; Cancer Vaccines; Cell Death; Clinical; Clinical Trials; Collaborations; Cross-Priming; Cytokine Gene; Data; Dendritic Cells; Disease; Disease Progression; Disease regression; Distal; Dopachrome isomerase; Engineering; Epitopes; Evaluation; Event; Evolution; Fostering; Gene-Modified; Human; Humoral Immunities; Immune; Immune System Diseases; Immune response; Immunity; Immunobiology; Immunologics; Immunosuppressive Agents; Immunotherapy; In Situ Lesion; Infiltration; Interferons; Interleukin-10; Interleukin-12; Interleukin-12 Gene; Interleukin-18; Lesion; Leukocytes; Liver; Localized; Lung; MDM2 gene; MDM2 gene; Maintenance; Mediating; Metastatic malignant neoplasm to brain; Modality; Modeling; Mus; Natural Killer Cells; Necrosis; Neoplasm Metastasis; Patients; Peptides; Primary Lesion; Primary Neoplasm; Proteins; Range; Rate; Receptor Protein-Tyrosine Kinases; Reporting; Research Personnel; Signal Pathway; Spleen; Staging; Systemic disease; T-Lymphocyte; T-Lymphocyte Epitopes; Testing; Therapeutic; Time; Tumor Angiogenesis; Tumor Antigens; Tumor Immunity; Universities; Vaccine Antigen; Vaccines; Variant; base; chemokine; cytokine; day; enzyme linked immunospot assay; gene therapy; human disease; improved; in vivo; insight; medical schools; melanoma; neoplastic cell; novel; paracrine; peptide based vaccine; prevent; programs; prospective; response; survivin; translational study; tumor; tumor progression

University of Pittsburgh School of Medicine

匹兹堡大学医学院