Emerging and High Risk Pathogens

新兴和高风险病原体

• 批准号: 7262328
• 负责人: MICHAEL R HOLBROOK
• 金额: $ 16.41万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-03 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7262328
• 关键词: biohazard control; biomedical facility; bioterrorism /chemical warfare; cooperative study; emerging infectious disease; training; biohazard control; biomedical facility; bioterrorism /chemical warfare; cooperative study; emerging infectious disease; training

The function of the Emerging and High-Risk Pathogens (EHRP) core is to provide oversight and operational management of GNL BSL-4 facilities. The EHRP Core will be responsible for organization of the experimental work and procedures performed within the BSL-4 facility, training of personnel accessing BSL-4, management of infectious agent stocks stored in BSL-4, provision of service and field activities related to BSL-4 agents and management of waste generated in BSL-4. The EHRP Core will function in close association with the GNL Advanced Veterinary Services (GAVS) Core, Advanced Imaging Core (1C), GNL Insectory Laboratories Core (GIL), Advanced Technologies Core (ATC), the Collaborative Research Services (CRS) Core and several Facilities Cores. The work performed in GNL BSL-4 will play a major role for the preparedness and response against high-risk pathogens by advancing our understanding toward the basic mechanisms of pathogen biology and pathogenesis, and developing countermeasures such as vaccines, therapeutics and diagnostics. The EHRP Core represents a major focus of research activities in the GNL. The EHRP Core will serve as a training and working site for US-based and international scientists, technical personnel and pre- and postdoctoral fellows that require practical laboratory experience or who would like to pursue BSL-4 research, but do not have facilities available. In addition, the GNL BSL-4 will also serve as a training site for engineers, maintenance/operating personnel and biocontainment/ biosafety personnel to learn about the complex inner-workings of a BSL-4 laboratory. In this way, the EHRP Core will provide a unique combined training/teaching and research environment

新兴和高风险病原体（EHRP）核心的功能是提供监督和操作 GNL BSL-4设施的管理。 EHRP核心将负责组织 在BSL-4设施中执行的实验工作和程序，培训访问人员 BSL-4，BSL-4中存储的传染代理股票的管理，提供服务和现场活动 与BSL-4代理和BSL-4中产生的废物的管理有关。 EHRP核心将在 与GNL高级兽医服务（GAVS）核心，高级成像核心（1C）的密切关联， GNL昆虫实验室核心（GIL），Advanced Technologies Core（ATC），协作研究 服务（CRS）核心和多个设施核心。在GNL BSL-4中执行的工作将扮演重要角色 通过促进我们对高风险病原体的准备和反应，通过促进我们的理解 病原体生物学和发病机理的基本机制，并开发对策 疫苗，治疗和诊断。 EHRP核心代表了研究活动的主要重点 GNL。 EHRP核心将作为美国和国际的培训和工作地点 需要实验室经验的科学家，技术人员以及前和博士后研究员 或谁想从事BSL-4研究，但没有可用的设施。另外，GNL BSL-4 还将作为工程师，维护/操作人员和生物内在的培训站点/ 生物安全人员了解BSL-4实验室的复杂内部工作。这样，EHRP 核心将提供独特的组合培训/教学和研究环境