A new device for metabolic monitoring in infants

一种用于婴儿代谢监测的新设备

• 批准号: 7013127
• 负责人: Russell Rising
• 金额: $ 28.87万
• 依托单位: EMTAC, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-10 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7013127
• 关键词: basal metabolism; bioenergetics; bioengineering /biomedical engineering; biomedical equipment development; body physical activity; calorimetry; clinical research; human subject; infant human (0-1 year); parent offspring interaction; patient monitoring device

DESCRIPTION (provided by applicant): Backqround. We have developed a novel instrument for energy expenditure measurements in infants The data obtained with this equipment has contributed significantly to the knowledge of infant metabolism and nutrition and has led to four scientific publications in highly ranked peer-reviewed journals. Specific aims: Our major objective is to fabricate the EMTAC 3000i which will be a more portable and user friendly instrument This will allow bedside, as well as metabolic measurements in both in and out patient settings In this manner the EMTAC will be used beyond the laboratory where Phase I testing took place In Phase II of this proposal we have outlined the engineering advancements in order to accomplish the development of the new equipment Moreover, we have established a relationship with three centers of excellence who will lend their resources and expertise to enrich and cross-fertilize the EMTAC These centers include The Sansum Medical Research Institute, Santa Barbara, California, The Primate Behavior Laboratory of the State University of New York, Brooklyn, NY and The Fima Lifshitz Metabolic Unit at The Hospital Universitario Professor Edgar Santos, Salvador, Bahia, Brazil In each one of these centers, the feasibility of EMTAC will be tested in specific models of nutritional entities These include infants born to obese and/or diabetic parents and an experimental animal model of obesity in primates On the other side of the nutritional spectrum, infants with severe primary malnutrition will be studied in Brazil These studies will provide additional data for the understanding of the pathophysiology of each of these entities, thereby helping to improve the health of children world wide The work proposed will also prove that the EMTAC is suitable for use in distant laboratories under a variety of conditions and will set the stage for developing market areas for this instrument Finally, we have already begun the process of obtaining patent protection for the EMTAC Furthermore, we will seek approvals from both the Federal Drug Administration as well as Underwriters Laboratory during the period of this application This is further outlined in a detailed product development plan that is included with this application Summary: We have already proven that the EMTAC is a viable tool in regards to infant energy expenditure assessments Future testing as proposed in this application will provide important information in regards to the performance of EMTAC in different environments Finally, the new work in experimental animals will prove that EMTAC is a viable instrument for use in areas not explored previously.

描述（由申请人提供）：背景。我们开发了一种用于测量婴儿能量消耗的新型仪器。用该设备获得的数据对婴儿新陈代谢和营养知识做出了重大贡献，并在高排名的同行评审期刊上发表了四篇科学出版物。 具体目标： 我们的主要目标是制造 EMTAC 3000i，这将是一款更便携、用户友好的仪器 这将允许在患者内外进行床边以及代谢测量 通过这种方式，EMTAC 将在实验室之外使用在该提案的第二阶段，我们概述了完成新设备开发的工程进展。此外，我们还与三个卓越中心建立了关系，他们将利用其资源和专业知识来丰富和发展新设备。交叉施肥EMTAC 这些中心包括加利福尼亚州圣巴巴拉市的 Sansum 医学研究所、纽约布鲁克林纽约州立大学的灵长类动物行为实验室以及巴西巴伊亚州萨尔瓦多大学医院的 Fima Lifshitz 代谢中心 Edgar Santos 教授每一个中心都将在特定的营养实体模型中测试 EMTAC 的可行性，这些模型包括肥胖和/或糖尿病父母所生的婴儿以及灵长类动物肥胖实验动物模型在营养谱系的另一边，巴西将研究患有严重原发性营养不良的婴儿。这些研究将为了解每个实体的病理生理学提供额外的数据，从而有助于改善全世界儿童的健康。拟议的工作还将证明 EMTAC 适合在各种条件下在远程实验室中使用，并将为该仪器开发市场领域奠定基础最后，我们已经开始为 EMTAC 获得专利保护的过程此外，我们将寻求批准联邦药物管理局以及保险商实验室在本申请期间这在本申请中包含的详细产品开发计划中得到了进一步概述 摘要：我们已经证明 EMTAC 是婴儿能量消耗评估的可行工具 本申请中提出的未来测试将提供有关 EMTAC 在不同环境中性能的重要信息 最后，实验动物中的新工作将证明 EMTAC 是一种可行的工具，可用于以前未探索过的领域。