BSL-3 Emerging Pathogens Research Facility

BSL-3 新兴病原体研究设施

• 批准号: 7001772
• 负责人: WINFRED M PHILLIPS
• 金额: $ 207.69万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001772
• 关键词: biohazard control; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation

DESCRIPTION (provided by applicant): This project is part of a 10-year master plan to expand, improve and modernize the University of Florida's animal research infrastructure. Recognizing that the CAF was in major need of renovations to correct HVAC deficiencies, outdated design, and other deficiencies including insufficient space, a three phase plan was devised with input from faculty and administration. Phase I is complete and provided new HVAC supply units with redundancy. Phase II will add a 62,975 gsf building, designed as a SPF barrier and designated the Annex, onto the existing CAF facility. Phase II is partially funded by the NIH with the remainder provided by the University. This phase is in the planning stage. Phase III has two parts and will reconfigure and modernize the existing CAF and replace the remainder of the worn out HVAC. Part I of Phase III is the subject of this proposal and will reconfigure, modernize and enlarge the ABSL3 suite in CAF to provide both BSL3 laboratories and ABSL3 animal rooms and support space. Part II of Phase III will reconfigure and modernize the remainder of the CAF facility including replacement of the remainder of the worn out HVAC. Over 120 Investigators currently use the CAF. Of these, 14 investigators have 22 active projects. All these projects support the NIAID biodefense and emerging infectious diseases agenda and will use the BRF to house their research animals. In addition, 11 investigators with 29 currently funded projects require BSL3/ABSL3 facilities to complete their work and would also benefit from this proposed project. This proposal requests partial funding for reconfiguration and enlargement of the existing CAF ABSL3 suite to create a BSL3 Research Facility (Part I of Phase III). The state of the art facility will upgrade the HVAC serving the suite to modern ABSL3 standards and incorporate a design that provides appropriate laboratory, support and animal housing space within the suite barrier. The support space will include imaging, flow cytometry and an aerosol challenge suite. This project will increase the available BSL3 laboratory space in the J. Hillis Miller Health Center by more than 60%. Two-thirds of the increased laboratory space will be will be immediately associated with an animal room to support the laboratory functions.

描述（由申请人提供）： 该项目是一项为期10年的总体规划的一部分，旨在扩展，改善和现代化佛罗里达大学动物研究基础设施。认识到CAF非常需要进行翻新，以纠正HVAC缺陷，过时的设计以及其他缺陷，包括空间不足，因此设计了三个相计划，并通过教职员工和管理的投入。第一阶段已完成，并为新的HVAC供应单元提供了冗余。第二阶段将在现有的CAF设施中添加62,975 GSF建筑物，设计为SPF屏障并指定为附件。第二阶段由NIH部分资助，并由大学提供。这个阶段处于计划阶段。第三阶段有两个部分，将重新配置并现代化现有的CAF，并取代损坏的HVAC的其余部分。第三阶段的第一部分是该提案的主题，将在CAF中重新配置，现代化和扩大ABSL3套件，以提供BSL3实验室和ABSL3动物室和支持空间。第三阶段的第二部分将重新配置并现代化CAF设施的其余部分，包括更换破旧的HVAC的其余部分。当前有120多名调查人员使用CAF。其中，有14名调查人员有22个活跃的项目。 所有这些项目都支持NIAID生物化和新兴的传染病议程，并将使用BRF来容纳其研究动物。此外，11位当前有29个资助项目的调查人员需要BSL3/ABSL3设施来完成其工作，还将从该拟议项目中受益。 该提案要求部分资金用于重新配置和扩大现有CAF ABSL3 Suite，以创建BSL3研究设施（III阶段的第一部分）。最先进的设施将升级HVAC，为现代ABSL3标准提供服务套件，并纳入了在套房障碍物内提供适当的实验室，支撑和动物住房空间的设计。支持空间将包括成像，流式细胞仪和气溶胶挑战套件。该项目将使J. Hillis Miller Health Center的可用BSL3实验室空间增加60％以上。增加实验室空间的三分之二将与动物室立即相关，以支持实验室功能。