Construct/BSL-3 Regional Biocontainment Lab/Pittsburgh

构造/BSL-3 区域生物防护实验室/匹兹堡

• 批准号: 7095634
• 负责人: DONALD SCOTT BURKE
• 金额: $ 408.23万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095634
• 关键词: Construct; BSL; Regional; Biocontainment; Lab

DESCRIPTION (provided by applicant):Funding is requested for completion of the seventh floor of a proposed biomedical science tower to expand BSL-3 laboratory and NHP housing space. Encompassing approximately 18,000 NSF, this area will contain the following: * 5 independent modules conforming to BSL-3 Ag requirements, each containing housing for 24 nonhuman primates (NHP), a procedure room, and laboratory to accommodate simultaneous, independent studies using BSL-3 agents. Animal support services for food preparation, a walk-thru autoclave/decontamination chamber, and cage washer are also included. * A BSL-3 rodent housing area. * A class III biological safety cabinet with ULPA filtered hood exhaust system for anthrax challenge experiments with NHP. * 10 self-contained BSL-3 laboratories equipped with dual Class II, type A2 laminar flow hoods with canopy connections. * BSL-3 common equipment rooms containing centrifuges and a flow cytometer with high speed sorting capability. * Warm and cold rooms. * Administrative office space This facility will enable fulfillment of our obligations as Simian Core for the Middle Atlantic Regional Center for Excellence for Biodefense and Infectious Diseases by providing a facility dedicated to biodefense research. It will also be open to researchers within and outside the University and enable the expansion of vaccine research directed toward Category A-C agents. Lastly, the BSL-3 laboratories will provide needed "surge capacity" in the event of a public health emergency by offering rapid access to trained personnel, laboratory facilities, and specialized equipment by augmenting existing hospital, state and regional laboratories within the Commonwealth of Pennsylvania and Allegheny County Health Departments.

描述（由申请人提供）：需要资金来完成拟议的生物医学科学塔的七楼，以扩大 BSL-3 实验室和 NHP 住房空间。该区域包含约 18,000 个 NSF，将包含以下内容： * 5 个符合 BSL-3 Ag 要求的独立模块，每个模块包含 24 只非人类灵长类动物 (NHP) 的住房、一个手术室和实验室，可容纳使用 BSL-3 制剂进行同时、独立的研究。还包括用于准备食物的动物支持服务、步行式高压灭菌器/净化室和笼子清洗机。 * BSL-3 啮齿动物居住区。 * III 级生物安全柜，配有 ULPA 过滤罩排气系统，用于 NHP 炭疽挑战实验。 * 10 个独立的 BSL-3 实验室，配备双 II 类 A2 型层流罩，带顶盖连接。 * BSL-3公用设备室，配有离心机和具有高速分选能力的流式细胞仪。 * 温暖和寒冷的房间。 * 行政办公空间 该设施将通过提供专门用于生物防御研究的设施，使我们能够履行作为中大西洋生物防御和传染病卓越区域中心猿猴核心的义务。它还将向大学内外的研究人员开放，并扩大针对 A-C 类药物的疫苗研究。最后，BSL-3 实验室将通过扩大宾夕法尼亚州现有的医院、州和地区实验室，提供快速获得训练有素的人员、实验室设施和专业设备，从而在发生公共卫生紧急情况时提供所需的“激增能力”和阿勒格尼县卫生部门。