Computational Models of Infectious Disease Threats

传染病威胁的计算模型

基本信息

批准号：
7908072
负责人：
DONALD SCOTT BURKE
金额：
$ 5.26万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-24 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7908072
关键词：
Administrative Coordination Americas Arts Avian Influenza Behavior Behavioral Cell Nucleus Centers for Disease Control and Prevention (U.S.)Collaborations Commit Communicable Diseases Communities Computer Simulation County Decision Making Education Education and Outreach Effectiveness Emergency Situation Environment Epidemic Evolution Government Health Policy Heterogeneity Human Human Resources Individual Institution Lawyers Leadership Methodology Methods Microbe Mission Modeling National Institute of General Medical Sciences Pennsylvania Performance Policies Policy Analysis Policy Maker Positioning Attribute Process Productivity Psychologist Public Health Readiness Research Research Personnel Resources Running Scientist Structure Students Supercomputing System Textiles Thinking Training United States Universities Variant Woman base behavior change college computerized tools experience flexibility improved infectious disease model member microbial pandemic disease prevent programs public health relevance simulation theories

项目摘要

DESCRIPTION (provided by applicant): This proposal for a Pittsburgh MIDAS Center of Excellence (U54) builds upon our proven track record of productivity in the NIGMS Modeling of Infectious Disease Agent Study "MIDAS" program. In that prior collaborative effort we successfully advanced both the theory and practice of epidemic modeling. We developed large scale agent-based simulations of a threatening avian influenza pandemic, used our models to evaluate potential epidemic control strategies, and advised the highest levels of the US Government and the WHO on public health policy. The senior investigators from our MIDAS team - Burke, Ferguson, and Epstein - constitute the nucleus of this proposed Center of Excellence. Research within the Center of Excellence is divided into seven project teams, each focusing on a specific component problem in computational modeling; all seven projects are complementary without duplication. Four of the projects (Parameters, Behavior, Evolution, and Environment) seek to model the dynamical processes and subprocesses of infectious disease epidemics, while three others (Decisions, Preparedness, Applied Modeling) seek to improve the utility of models in public health policy decision-making. A unique feature of this Center of Excellence is its exceptionally interdisciplinary character; there is vigorous participation of behavioral scientists, psychologists, lawyers, and public health practitioners, and there are strong collaborations with public health agencies at the county (Allegheny), state (Pennsylvania) and national (CDC) levels. Three cores (Administrative; Education, Training, & Outreach; Computing) provide support across the Center. Key personnel are drawn from the University of Pittsburgh, Carnegie Mellon University, the Pittsburgh Supercomputing Center, Johns Hopkins University, the Brookings Institution, and Imperial College, all outstanding research institutions. We are well positioned to provide continued leadership in the renewed MIDAS network, and we are deeply committed to collaborative research not only within our own Center of Excellence but across the entire MIDAS network structure. PUBLIC HEALTH RELEVANCE: The mission of the Pittsburgh MIDAS Center of Excellence is to protect the United States of America and the global community against communicable infectious disease threats. We will do this by improving our nation's ability to predict potential epidemics, to devise strategies to prevent the emergence or re-emergence of pathogenic microbes, and to respond rapidly - when necessary - to mitigate the impact of a spreading epidemic.

描述（由申请人提供）：匹兹堡 MIDAS 卓越中心 (U54) 的这项提案建立在我们在 NIGMS 传染病病原体建模研究“MIDAS”计划中经过验证的生产力记录之上。在之前的合作中，我们成功地推进了流行病模型的理论和实践。我们开发了基于代理的大规模禽流感大流行模拟，使用我们的模型评估潜在的流行病控制策略，并就公共卫生政策向美国政府和世界卫生组织最高层提供建议。我们的 MIDAS 团队的高级研究人员 - Burke、Ferguson 和 Epstein - 构成了这个拟议的卓越中心的核心。卓越中心的研究分为七个项目团队，每个团队都专注于计算建模中的特定组成问题；所有七个项目都是互补的，没有重复。其中四个项目（参数、行为、进化和环境）寻求对传染病流行的动态过程和子过程进行建模，而其他三个项目（决策、准备、应用建模）寻求提高模型在公共卫生政策决策中的实用性-制作。该卓越中心的一个独特之处在于其独特的跨学科特征；行为科学家、心理学家、律师和公共卫生从业者的积极参与，并与县（阿勒格尼）、州（宾夕法尼亚州）和国家（疾病预防控制中心）各级的公共卫生机构开展了强有力的合作。三个核心（行政；教育、培训和外展；计算）为整个中心提供支持。主要人员来自匹兹堡大学、卡内基梅隆大学、匹兹堡超级计算中心、约翰·霍普金斯大学、布鲁金斯学会、帝国理工学院等优秀研究机构。我们处于有利地位，可以在更新的 MIDAS 网络中提供持续的领导地位，并且我们不仅致力于在我们自己的卓越中心内而且在整个 MIDAS 网络结构中进行合作研究。公共卫生相关性：匹兹堡 MIDAS 卓越中心的使命是保护美利坚合众国和全球社会免受传染病威胁。为此，我们将提高国家预测潜在流行病的能力，制定防止病原微生物出现或再次出现的策略，并在必要时迅速做出反应，以减轻流行病蔓延的影响。