Innovative Nursery-Rearing for Improving Rhesus Macaques as Biomedical Models

创新型保育饲养以提高恒河猴作为生物医学模型的能力

• 批准号: 7450649
• 负责人: Brenda McCowan
• 金额: $ 22.65万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7450649
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adult; Age; Age-Months; Animals; Auditory; Basic Science; Behavior; Behavioral; Biomedical Engineering; Birth; Bite; Breeding; Child health care; Cognitive; Condition; Coping Skills; Data; Depth; Development; Emotional; Environment; Exhibits; Feedback; Funding; Future; Generations; Goals; Health; Heating; Home environment; Hour; Human; Human Development; Incubators; Individual; Infant; Investigator-Initiated Research; Lead; Learning; Life; Macaca; Macaca mulatta; Mental Health; Modeling; Monitor; Monkeys; Monoclonal Antibody R24; Mothers; Motor; National Center for Research Resources; Nipples; Nurseries; Outcome; Pathology; Pattern; Personal Satisfaction; Personality; Physiological; Population; Primates; Problem behavior; Public Health; Research; Research Personnel; Research Project Grants; Retroviridae; Role; SIV; Sample Size; Secure; Sensory; Shapes; Social Development; Social Environment; Social Welfare; Specific Pathogen Frees; Specific qualifier value; Standards of Weights and Measures; System; Tactile; Technology; Temperament; Testing; Thinking; Visual; Work; base; coping; cost; critical developmental period; day; deprivation; design; design and construction; follow-up; germ free condition; grasp; improved; innovation; novel; peer; programs; psychologic; reproductive success; research study; response; skills; social; social deprivation; social group; social skills; success; sucking; tool; vibration

DESCRIPTION (provided by applicant): A major goal of the National Center for Research Resources (NCRR) is to maintain successful breeding programs at NCRR-funded primate centers for specific-pathogen-free (SPF) macaque monkeys that are free of common retroviruses that can interfere with AIDS experiments and other types of research. SPF colonies are currently established by raising infants without their non-SPF mothers. Therefore, key to the long-term success of establishing and maintaining these SPF colonies is to develop efficacious strategies for raising infant monkeys in ways which minimize the emergence of behavioral pathologies due to social deprivation of their mothers and which will lead to the development of social competence. Such strategies are crucial to the long-term health and success of these colonies for two reasons: (1) social competence of individuals is critical for promoting social stability in groups, which optimizes overall colony reproductive success and (2) nursery-reared individuals develop different psychological, physiological and immunological responses than their mother-peer reared counterparts, which could interfere with and thus confound the studies to which these animals are assigned. Two key features appear to be most critical for infants in developing proper social and coping skills, minimizing abnormal behavior and developing appropriate physiological and immunological systems: (1) an appropriate and secure attachment figure which provides species specific sensory stimulation and (2) unambiguous response-contingent relationships during interactions with the attachment figure (mother or surrogate) and peers that permit infants some control over and predictability and feedback from their environment. We propose to utilize these two critical features in developing and testing a new set of nursery-rearing strategies that will maximize the development of coping skills and social competence, minimize abnormal behavior and enhance physiological and immunological potency in nursery-reared SPF rhesus macaques. The proposed study will lead to the development of an interactive surrogate-peer rearing design that will provide both an attachment figure to the infant as well as response-contingency relationships with the attachment figure (surrogate) and peers. Providing these features during early development should result in nursery-reared infants with more normal social, motor, perceptual and cognitive skills than nursery-reared infants without these features. Infants raised to be more similar to their mother-peer reared counterparts will provide investigators with a better biomedical model as well as the development of more socially competent individuals in social groups for breeding subsequent generations of SPF animals. Both of these outcomes address two of the three R's, reduction and refinement, and enhances the welfare of the rhesus population both on an individual basis and the colony as a whole. With further research as an R24, this research could lead to a patentable product for use at this and other NPRCs and primate facilities. This research could also lead to significant basic research as an R01 on the necessary and sufficient conditions required for normal infant social, motor, perceptual and cognitive development that would be applicable to child health and human development. PUBLIC HEALTH RELEVANCE: The relevance of this proposed research to human health is two-fold. First, this research will lead to the improvement of the rhesus macaque as a biomedical model which is the leading model at primate centers for investigating human health issues. Second, this research will lead to future projects that will directly enhance human health by providing a deeper understanding of the features of caretakers that are necessary during early development to promote psychological health and well-being in humans throughout life.

描述（由申请人提供）：国家研究资源中心（NCRR）的一个主要目标是在NCRR资助的灵长类动物中心维持成功的育种计划，用于没有特定pathogen（SPF）的猕猴，这些猴子没有可以干扰AIDS实验和其他类型的研究的常见逆转录病毒。 SPF殖民地目前是通过养育没有非SPF母亲的婴儿来建立的。因此，建立和维持这些SPF殖民地的长期成功的关键是制定有效的策略来养育婴儿猴子，从而最大程度地减少由于其母亲的社会剥夺而导致行为病理的出现，这将导致社会能力的发展。这些策略对于这些殖民的长期健康和成功至关重要，原因有两个：（1）个人的社会能力对于促进群体的社会稳定至关重要，这可以优化整体殖民地生殖成功，并且（2）托儿所的人在心理，生理和免疫学的反应中产生不同的心理，生理和免疫反应，而不是母亲养育的动物，而这些动物可能会构成这些研究，从而使这些研究构成了这些研究。两个关键特征似乎对于婴儿发展适当的社会和应对能力，最大程度地减少了行为和免疫系统的适当和免疫系统：（1）适当且安全的依恋图形，该图形提供特定物种的感觉刺激，以及（2）在与依恋图（母亲或替代者）和pee的互动过程中，允许对依从性和预测的互动过程中的互动互动中的明确响应响应，并提供了一些预测，并提供了一些预测性和抚养性。我们建议利用这两个关键特征来开发和测试一套新的育苗策略，以最大程度地发展应对技能和社会能力，最大程度地减少异常行为并增强育苗的SPF SPF RheSus Macaques中的生理和免疫学效力。拟议的研究将导致发展互动替代饲养设计的发展，该设计将为婴儿提供依恋图，以及与依恋图（替代）和同伴的响应 - 换态关系。在早期开发期间提供这些功能应导致与没有这些特征的托儿所饲养的婴儿相比，具有更正常的社交，运动，感知和认知能力的苗圃婴儿。提出的婴儿与母亲饲养的对应物更为相似，将为研究人员提供更好的生物医学模型，以及在社会群体中发展更具社会胜任的人，以繁殖随后的SPF动物。这两个结果都涉及三个R中的两个，即减少和改进，并以个人和整个殖民地的福利为基础。通过作为R24的进一步研究，这项研究可能会导致可在此和其他NPRC和灵长类设施中使用的可专利产品。这项研究还可能导致重大的基础研究作为R01，对正常婴儿社会，运动，感知和认知发展所需的必要条件，适用于儿童健康和人类发展。公共卫生相关性：这项拟议研究与人类健康的相关性是两个方面。首先，这项研究将导致恒河猴作为生物医学模型的改善，该模型是灵长类动物中心研究人类健康问题的主要模型。其次，这项研究将导致未来的项目，这些项目将通过对看护人的特征有更深入的了解，这些项目将在早期发展过程中有必要的人的特征，以促进人类的心理健康和福祉。