Highly Sensitive Biosensor Platform Using Optical Microring Resonators

使用光学微环谐振器的高灵敏度生物传感器平台

• 批准号: 7476306
• 负责人: Ian M White
• 金额: $ 10.7万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7476306
• 关键词: Appointment; Architecture; Arts; Award; Behavior; Biocompatible Materials; Biological Markers; Biological Models; Biological Sciences; Biophotonics; Biosensor; Breast Cancer Detection; Chemicals; Class; Collection; Consumption; DNA; Detection; Development; Diagnosis; Disclosure; Disease; Doctor of Philosophy; Drug Design; Early Diagnosis; Electrical Engineering; Exhibits; Faculty; Fellowship; Fluorescence; Goals; Human; Industry; Journals; K-Series Research Career Programs; Knowledge; Label; Light; Medical; Mentors; Metals; Microspheres; Missouri; Monitor; Nanostructures; Nanotechnology; Nucleotides; Optics; Prevention; Property; Publications; Quantum Dots; Raman Spectrum Analysis; Range; Relative (related person); Research; Sampling; Science; Screening for cancer; Surface; Techniques; Technology; Thrombin; Time; Today; Training; Universities; Work; base; career; design; detector; environmental chemical; experience; member; neoplastic cell; new technology; novel; optical sensor; photonics; programs; sensor; single molecule; size; small molecule; success; symposium; tool

DESCRIPTION (provided by applicant): This mentored career development award offers an excellent path for me to transition into the field of biomedical sciences. I received my Ph.D. in electrical engineering and then spent three years in industry applying photonics technology to networks. Despite a successful beginning to my career, as exhibited by my publications, awards, and invention disclosures, the research landscape was unappealing to me. As a result, ten months ago I began a new career upon obtaining the University of Missouri Life Sciences Postdoctoral Fellowship with an appointment to the biophotonics lab of Prof. Xudong Fan, the sponsor on this application. Our research focuses on the development of optical sensors with chemical, environmental, and biomedical applications. During the short time that I have been here, I have four first-authored journal publications and several others as a co-author. Additionally, I have delivered three presentations at highly attended conferences and I have been a co-inventor on three invention disclosures filed with the university. This initial success is only a small step towards my ultimate goal of becoming a faculty member and leading a research group that is applying photonics and nanotechnology to biomedical applications. Currently, a gap in knowledge, training, and experience exists. However, in this application, I believe that I have designed a program to enable me to acquire the training that I need to accomplish my career goals. We will experimentally investigate three classes of optical sensors, including label-free sensors, fluorescent quantum dot sensors, and surface enhanced Raman spectroscopy sensors. All three of our sensor architectures are based on optical ring resonators, a relatively new technology platform utilizing the resonating modes of light in micro-sized dielectric objects. We will be working towards the ultimate goal of applying the ring resonator sensing technology for the detection of circulating tumor cells. Accomplishing this would offer medical practitioners a simple tool for earlier detection of cancer, as well as the capability to monitor treatment progress more effectively. We have assembled an excellent collection of project sponsors and collaborators to assist in accomplishing this aggressive research goal, as well as to support me in my mentored career development. Relevance: The technological advances resulting from this project will enable new applications not possible today for disease diagnosis, treatment, and prevention. Respective examples include the detection of trace amounts of biomarkers for early disease diagnosis, the detection of small molecules for drug design, and the identification of single DNA nucleotides for advancing the possibilities with DNA studies.

描述（由申请人提供）： 这个指导的职业发展奖为我过渡到生物医学科学领域提供了绝佳的道路。我获得了博士学位在电气工程领域，然后在行业工作了三年，将光子技术技术应用于网络。尽管我的职业生涯成功了，这是我的出版物，奖项和发明披露的展示，但研究格局对我来说并没有吸引人。结果，十个月前，我开始了新的职业生涯，从而获得了密苏里大学生活科学博士后研究金，并任命了该申请的赞助商Xudong Fan教授的生物光学实验室。我们的研究重点是使用化学，环境和生物医学应用的光传感器开发。在我来这里的短时间内，我有四本初学的日记出版物，还有其他几个作为合着者。此外，我在高度参加会议上发表了三个演讲，并且我是向大学提交的三项发明披露的共同发明。最初的成功只是我迈出的最终目标的一小步，即成为一名教师并领导一个将光子学和纳米技术应用于生物医学应用的研究小组。目前，存在知识，培训和经验的差距。但是，在此应用程序中，我相信我已经设计了一个程序来使我能够获得完成职业目标所需的培训。我们将通过实验研究三类的光学传感器，包括无标签传感器，荧光量子点传感器和表面增强的拉曼光谱传感器。我们所有的三个传感器架构均基于光圈谐振器，这是一个相对较新的技术平台，利用微型介电对象中的光模式。我们将致力于将环谐振器传感技术应用于循环肿瘤细胞的最终目标。实现这一目标将为医生提供一个简单的工具，用于早期检测癌症，并能够更有效地监测治疗进展。我们汇集了一系列的项目赞助商和合作者，以协助实现这一积极的研究目标，并为我的指导职业发展提供支持。相关性：该项目产生的技术进步将使今天无法进行疾病诊断，治疗和预防的新应用。各自的例子包括检测用于早期疾病诊断的痕量生物标志物，用于药物设计的小分子的检测以及鉴定单个DNA核苷酸，用于通过DNA研究提高可能性。