Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome

用于评估创伤引起的急性呼吸窘迫综合征风险的护理点系统

基本信息

批准号：
10594793
负责人：
Ian M White
金额：
$ 39.28万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10594793
关键词：
Accident and Emergency department Acute Acute Respiratory Distress Syndrome Admission activity Alkanes Anti-Inflammatory Agents Antibodies Automation Benchmarking Binding Biological Assay Blood Blood Vessels Blood capillaries Blood specimen Body part Cell Death Cells Circulation Clinical Cytolysis DNA Data Death Rate Detection Diagnostic Early Diagnosis Edema Environment Enzyme-Linked Immunosorbent Assay Fingers Freeze Drying Goals Hemorrhage Heparin Histones Immune Incidence Infection Inflammatory Response Injury Intellectual Property Investments Label Life Link Lung Manuals Measurement Measures Morbidity - disease rate Operating Rooms Optics Organ Outcome Patient risk Patients Performance Phase Point-of-Care Systems Preventive treatment Reagent Refrigeration Reporting Research Respiration Disorders Risk Risk Assessment Sampling Secure Shock Syndrome System Technology Temperature Thrombosis Trauma Trauma patient Traumatic injury Tube Vacuum Validation Venous Whole Blood commercialization design diagnostic technologies diagnostic tool improved innovation instrument invention lung failure lung injury meetings mortality neutrophil point of care point of injury portability preservation prevent prototype sample collection trauma centers

Accident and Emergency department Acute Acute Respiratory Distress Syndrome Admission activity Alkanes Anti-Inflammatory Agents Antibodies Automation Benchmarking Binding Biological Assay Blood Blood Vessels Blood capillaries Blood specimen Body part Cell Death Cells Circulation Clinical Cytolysis DNA Data Death Rate Detection Diagnostic Early Diagnosis Edema Environment Enzyme-Linked Immunosorbent Assay Fingers Freeze Drying Goals Hemorrhage Heparin Histones Immune Incidence Infection Inflammatory Response Injury Intellectual Property Investments Label Life Link Lung Manuals Measurement Measures Morbidity - disease rate Operating Rooms Optics Organ Outcome Patient risk Patients Performance Phase Point-of-Care Systems Preventive treatment Reagent Refrigeration Reporting Research Respiration Disorders Risk Risk Assessment Sampling Secure Shock Syndrome System Technology Temperature Thrombosis Trauma Trauma patient Traumatic injury Tube Vacuum Validation Venous Whole Blood commercialization design diagnostic technologies diagnostic tool improved innovation instrument invention lung failure lung injury meetings mortality neutrophil point of care point of injury portability preservation prevent prototype sample collection trauma centers

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项目摘要

PROJECT SUMMARY/ABSTRACT Trauma-induced acute respiratory dysfunction syndrome (ARDS) is a deadly condition in which lung failure results from a traumatic injury to another part of the body. Recently, several studies have established a link between circulating histones and lung failure. Traumatic injuries cause a massive amount of cell death, resulting in the release of high concentrations of histones into circulation, which can directly lead to ARDS, as histones damage the lungs. In addition, circulating histones exacerbate exaggerated pro- and anti- inflammatory responses that also result in damage to the lungs and other organs. Identification and quantification of trauma-triggered circulating histones would provide an approach to assess the risk of ARDS, which could enable life-saving therapies before a patient develops ARDS. Diagnostic solutions to provide early detection of histones following trauma should be portable and rapid in order to assess the patient soon after the injury occurs. Currently, however, there are no portable and rapid approaches that enable detection of circulating histones to assess a trauma patient’s risk of developing ARDS. Our goal is to develop a diagnostic tool that is capable of quantitatively assessing the risk of trauma-induced ARDS at the point of care. This may include at the point of injury, in the transport vehicle to a trauma center, in the Emergency Department (ED), or in the operating room (OR). We have invented a Portable Histone Assay Technology (PHAST) that can quantify circulating histones directly from whole blood within 30 minutes. .

项目摘要/摘要创伤引起的急性呼吸障碍综合征（ARDS）是一种致命的疾病由于创伤性损伤导致身体另一部分。最近，一些研究建立了一个链接在循环组蛋白和肺衰竭之间。创伤性损伤会导致大量细胞死亡，导致高浓度组蛋白释放到循环中，这可以直接导致ARDS，例如组蛋白会损害肺部。此外，循环组蛋白加剧了促进和抗炎症反应也会损害肺部和其他组织。识别和量化创伤触发的循环组蛋白将提供一种评估ARDS风险的方法，这可以在患者发展ARDS之前实现挽救生命的疗法。诊断解决方案以提早提供创伤后的组蛋白的检测应该是便携式和快速的，以便不久之后评估患者受伤发生。但是，目前尚无便携式和快速的方法来检测循环组蛋白评估创伤患者患ARDS的风险。我们的目标是开发诊断能够在护理点上定量评估创伤引起的ARD的风险的工具。这可能包括受伤点，在运输工具到创伤中心，急诊科（ED）或在手术室（或）。我们发明了一种便携式组蛋白测定技术（PHAST），可以在30分钟内直接从全血中量化循环组蛋白。。