Highly Sensitive Biosensor Platform Using Optical Microring Resonators

使用光学微环谐振器的高灵敏度生物传感器平台

• 批准号: 7197773
• 负责人: Ian M White
• 金额: $ 9.4万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7197773
• 关键词: DNA; biomarker; career; diagnosis; drug design /synthesis /production; early diagnosis; microcapsule; nanotechnology; neoplasm /cancer; nucleotides; prevention; publications; training; university

DESCRIPTION (provided by applicant): This mentored career development award offers an excellent path for me to transition into the field of biomedical sciences. I received my Ph.D. in electrical engineering and then spent three years in industry applying photonics technology to networks. Despite a successful beginning to my career, as exhibited by my publications, awards, and invention disclosures, the research landscape was unappealing to me. As a result, ten months ago I began a new career upon obtaining the University of Missouri Life Sciences Postdoctoral Fellowship with an appointment to the biophotonics lab of Prof. Xudong Fan, the sponsor on this application. Our research focuses on the development of optical sensors with chemical, environmental, and biomedical applications. During the short time that I have been here, I have four first-authored journal publications and several others as a co-author. Additionally, I have delivered three presentations at highly attended conferences and I have been a co-inventor on three invention disclosures filed with the university. This initial success is only a small step towards my ultimate goal of becoming a faculty member and leading a research group that is applying photonics and nanotechnology to biomedical applications. Currently, a gap in knowledge, training, and experience exists. However, in this application, I believe that I have designed a program to enable me to acquire the training that I need to accomplish my career goals. We will experimentally investigate three classes of optical sensors, including label-free sensors, fluorescent quantum dot sensors, and surface enhanced Raman spectroscopy sensors. All three of our sensor architectures are based on optical ring resonators, a relatively new technology platform utilizing the resonating modes of light in micro-sized dielectric objects. We will be working towards the ultimate goal of applying the ring resonator sensing technology for the detection of circulating tumor cells. Accomplishing this would offer medical practitioners a simple tool for earlier detection of cancer, as well as the capability to monitor treatment progress more effectively. We have assembled an excellent collection of project sponsors and collaborators to assist in accomplishing this aggressive research goal, as well as to support me in my mentored career development. Relevance: The technological advances resulting from this project will enable new applications not possible today for disease diagnosis, treatment, and prevention. Respective examples include the detection of trace amounts of biomarkers for early disease diagnosis, the detection of small molecules for drug design, and the identification of single DNA nucleotides for advancing the possibilities with DNA studies.

描述（由申请人提供）： 这个指导性职业发展奖为我过渡到生物医学领域提供了一条极好的道路。我获得了博士学位。获得电气工程学士学位，然后在工业界工作了三年，将光子技术应用于网络。尽管我的职业生涯有一个成功的开端，正如我的出版物、奖项和发明披露所表明的那样，但研究领域对我来说并没有吸引力。结果，十个月前，我获得了密苏里大学生命科学博士后奖学金，并被任命到该申请的资助者范旭东教授的生物光子学实验室，开始了新的职业生涯。我们的研究重点是开发具有化学、环境和生物医学应用的光学传感器。在我来到这里的短时间内，我以第一作者的身份发表了四篇期刊论文，并作为合著者发表了几篇论文。此外，我还在出席率很高的会议上发表了三场演讲，并且是向大学提交的三项发明披露的共同发明人。这一初步的成功只是我向成为一名教员并领导一个将光子学和纳米技术应用于生物医学应用的研究小组的最终目标迈出的一小步。目前，在知识、培训和经验方面存在差距。然而，在这个应用程序中，我相信我设计了一个计划，使我能够获得实现我的职业目标所需的培训。我们将通过实验研究三类光学传感器，包括无标记传感器、荧光量子点传感器和表面增强拉曼光谱传感器。我们的所有三种传感器架构均基于光学环形谐振器，这是一种相对较新的技术平台，利用微型介电物体中的光谐振模式。我们将致力于实现应用环形谐振器传感技术检测循环肿瘤细胞的最终目标。实现这一目标将为医生提供一种早期检测癌症的简单工具，并能够更有效地监测治疗进展。我们聚集了一批优秀的项目发起人和合作者，以协助实现这一积极的研究目标，并支持我在指导下的职业发展。相关性：该项目带来的技术进步将实现目前在疾病诊断、治疗和预防方面不可能实现的新应用。各自的例子包括检测用于早期疾病诊断的微量生物标志物、检测用于药物设计的小分子以及识别单个DNA核苷酸以推进DNA研究的可能性。