Comorbidity of Mental Disorders and Pain

精神障碍和疼痛的合并症

基本信息

批准号：
7486837
负责人：
ROBERT Joseph GATCHEL
金额：
$ 24.67万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2009-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7486837
关键词：
Address Area Award Back Pain Chronic Disease Clinical Research Comorbidity Complex Development Disability Evaluation Early Diagnosis Early Intervention Functional Magnetic Resonance Imaging Future Goals Health Healthy People 2000 Healthy People 2010 Independent Scientist Award Intervention Intervention Studies Mental Health Mental disorders Military Personnel Modeling Musculoskeletal Pain National Institute of Mental Health Pain Pain Disorder Population Randomized Controlled Clinical Trials Reporting Research Research Priority Research Project Grants Senior Scientist Award Stress Technology Temporomandibular Joint Disorders Translational Research United States National Institutes of Health biopsychosocial chronic pain cost effectiveness health related quality of life heuristics improved prevent programs theories

项目摘要

DESCRIPTION (provided by applicant): This request for an NIMH Senior Scientist Award (K05) focuses on better understanding the biopsychosocial mechanisms associated with the comorbidity of mental disorders and complex pain problems. The program addresses Goal 1 of "Healthy People 2010: Understanding and Improving Health"--to improve health-related quality of life, with a special focus on comorbid mental health disorders and one of the most prevalent and costly forms of pain (chronic back pain). We will also focus on successful translational intervention research, which is a high priority of NIH. My ongoing biopsychosocial research program investigating the comorbidity of mental disorders and pain contains four inter-related components: early intervention translational research; cost-effectiveness translational research; underlying neuromatrix model-related research; and fMRI research. To that end, we will pursue three separate research projects over the next five years and beyond: preventing comorbid mental disorders and physical health disability; an evaluation and early intervention study of comorbid psychiatric and temporomandibular (TMD) disorders; and a randomized trial of comorbid mental disorders and musculoskeletal pain intervention in a military population. All of these projects will focus on early detection to prevent the development of such chronic disorders, recognized as a high priority research area in the PHS Report of "Healthy People 2000." Many of my current and future research projects will also evaluate a potentially heuristic theory of the interaction between pain and stress (the neuromatrix model of pain). In addition, we plan to use new fMRI technology in our future research projects to develop a more comprehensive understanding of biopsychosocial mechanisms of comorbid mental disorders and pain. This Award will enable me to maintain the momentum and clinical research advances of two previous consecutive K02 awards from NIMH.

描述（由申请人提供）：NIMH高级科学家奖（K05）的要求重点是更好地了解与精神障碍和复杂疼痛问题的合并症相关的生物心理社会机制。该计划解决了“ Healthy People 2010：了解和改善健康”的目标1，以改善与健康相关的生活质量，特别关注合并症的心理健康障碍，并且是最普遍，最昂贵的疼痛形式之一（慢性背痛）。我们还将专注于成功的翻译干预研究，这是NIH的高优先事项。我正在进行的生物心理社会研究计划研究了精神障碍和疼痛的合并症，其中包含四个相关组成部分：早期干预转化研究；成本效益转化研究；基础神经瘤模型相关研究；和fMRI研究。为此，我们将在未来五年及以后进行三个独立的研究项目：防止合并症和身体健康障碍；合并症和颞下颌（TMD）疾病的评估和早期干预研究；以及对军人的合并性精神障碍和肌肉骨骼疼痛干预的随机试验。所有这些项目都将着重于早期检测，以防止这种慢性疾病的发展，这在“健康人2000”的PHS报告中被认为是高优先研究领域。我当前和未来的许多研究项目还将评估疼痛与压力之间相互作用的潜在启发式理论（疼痛的Neuromatrix模型）。此外，我们计划在未来的研究项目中使用新的fMRI技术，以对合并症精神障碍和疼痛的生物心理社会机制有更全面的了解。该奖项将使我能够维持NIMH之前连续两个K02奖的势头和临床研究进展。