Comorbidity of Mental Disorders and Pain

精神障碍和疼痛的合并症

• 批准号: 6816766
• 负责人: ROBERT Joseph GATCHEL
• 金额: $ 23.17万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6816766
• 关键词: alternative medicine; analgesia; backache; biofeedback; chronic pain; clinical research; clinical trials; cognitive behavior therapy; comorbidity; coping; disabling disease; early diagnosis; functional magnetic resonance imaging; human subject; human therapy evaluation; medical rehabilitation related tag; mental disorders; musculoskeletal disorder; neuroanatomy; outcomes research; patient oriented research; psychosocial rehabilitation; quality of life; temporomandibular joint syndrome; vocational rehabilitation

DESCRIPTION (provided by applicant): This request for an NIMH Senior Scientist Award (K05) focuses on better understanding the biopsychosocial mechanisms associated with the comorbidity of mental disorders and complex pain problems. The program addresses Goal 1 of "Healthy People 2010: Understanding and Improving Health"--to improve health-related quality of life, with a special focus on comorbid mental health disorders and one of the most prevalent and costly forms of pain (chronic back pain). We will also focus on successful translational intervention research, which is a high priority of NIH. My ongoing biopsychosocial research program investigating the comorbidity of mental disorders and pain contains four inter-related components: early intervention translational research; cost-effectiveness translational research; underlying neuromatrix model-related research; and fMRI research. To that end, we will pursue three separate research projects over the next five years and beyond: preventing comorbid mental disorders and physical health disability; an evaluation and early intervention study of comorbid psychiatric and temporomandibular (TMD) disorders; and a randomized trial of comorbid mental disorders and musculoskeletal pain intervention in a military population. All of these projects will focus on early detection to prevent the development of such chronic disorders, recognized as a high priority research area in the PHS Report of "Healthy People 2000." Many of my current and future research projects will also evaluate a potentially heuristic theory of the interaction between pain and stress (the neuromatrix model of pain). In addition, we plan to use new fMRI technology in our future research projects to develop a more comprehensive understanding of biopsychosocial mechanisms of comorbid mental disorders and pain. This Award will enable me to maintain the momentum and clinical research advances of two previous consecutive K02 awards from NIMH.

描述（由申请人提供）：申请 NIMH 高级科学家奖 (K05) 的重点是更好地理解与精神障碍和复杂疼痛问题共病相关的生物心理社会机制。该计划致力于实现“2010年健康人：了解和改善健康”的目标1——改善与健康相关的生活质量，特别关注共存的精神健康障碍以及最普遍和最昂贵的疼痛形式之一（慢性背痛）疼痛）。我们还将重点关注成功的转化干预研究，这是 NIH 的高度优先事项。我正在进行的生物心理社会研究项目调查精神障碍和疼痛的共病，包含四个相互关联的组成部分：早期干预转化研究；成本效益转化研究；神经基质模型相关基础研究；和功能磁共振成像研究。为此，我们将在未来五年及以后开展三个独立的研究项目：预防共病精神障碍和身体健康残疾；共病精神疾病和颞下颌（TMD）疾病的评估和早期干预研究；以及对军人共病精神障碍和肌肉骨骼疼痛干预的随机试验。所有这些项目都将侧重于早期检测，以预防此类慢性疾病的发展，这在 PHS 报告《健康人 2000》中被视为高度优先的研究领域。我当前和未来的许多研究项目还将评估疼痛与压力之间相互作用的潜在启发式理论（疼痛的神经基质模型）。此外，我们计划在未来的研究项目中使用新的功能磁共振成像技术，以更全面地了解共病精神障碍和疼痛的生物心理社会机制。该奖项将使我能够保持之前连续两次获得 NIMH K02 奖项的势头和临床研究进展。