Genetic and Pathophysiologic Investigation of Panic Disorder Typologies

惊恐障碍类型的遗传学和病理生理学研究

基本信息

批准号：
7470794
负责人：
Roxann Roberson-Nay
金额：
$ 15.8万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7470794
关键词：
Address Adult Age of Onset Agoraphobia Anxiety Disorders Area Award Behavioral Genetics Behavioral Symptoms Biological Markers Candidate Disease Gene Categories Characteristics Childhood Classification Scheme Clinical Clinical Investigator Collection Comorbidity Data Data Set Derealizations Development Diagnosis Dizziness Doctor of Medicine Environment Environmental Risk Factor Epidemiology Family history of Fright Future Genetic Genetic Research Goals Institutes Instruction Investigation Knowledge Learning Literature Major Depressive Disorder Mental disorders Mentored Research Scientist Development Award Mentors Mentorship Methods Molecular Genetics Neurobehavioral Manifestations Numbers Panic Panic Attack Panic Disorder Parenting behavior Patients Pattern Personality Persons Prevalence Principal Investigator Purpose Race Range Recording of previous events Recurrence Reporting Research Research Personnel Research Training Respiratory physiology Risk Risk Factors Sample Size Sampling Statistical Methods Structure Substance abuse problem Symptoms Testing Time Training Training Programs Treatment Efficacy Twin Multiple Birth Typology Universities Validation Virginia Woman base childhood anxiety clinically relevant design disease classification disorder subtype experience genetic epidemiology improved innovation men neural circuit neuroimaging neurophysiology panic disorder with agoraphobia programs psychogenetics response sex skills suicidal risk trait

项目摘要

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Development Award proposes to provide advanced research training in psychiatric and molecular genetics with a research focus on panic disorder (PD). Dr. Kenneth S. Kendler, M.D., a world renowned researcher in psychiatric genetics, will serve as Dr. Roxann Roberson-Nay's primary mentor. The training will take place at the Virginia Institute for Psychiatric and Behavioral Genetics of Virginia Commonwealth University, which provides a rich, stimulating environment for the conduct of training and research. This application outlines a training program that will enable Dr. Roberson-Nay to combine her previous clinical experience in anxiety disorders research and neuroimaging with newly acquired skills in psychiatric and molecular genetics. The proposed training goals will provide further instruction and mentorship in five areas: a.) epidemiology/genetic epidemiology, b.) association methods, c.) molecular genetics, d.) respiratory physiology and neurophysiology, and e.) responsible conduct of research. The research focus of the award is on PD, a debilitating psychiatric disorder characterized by unexpected, recurrent panic attacks. For her research aims, the investigator will take a multimethod approach to the study of PD typologies wherein she will examine the phenotypic variance in PD for the purpose of identifying clinically relevant and meaningful subtypes. These results will be used to guide a multimodal approach to the examination of PD typologies. That is, the investigator will examine risk factors and progression of PD typologies as well as seek to identify mechanisms (i.e., genetic, environmental) that confer vulnerability to them. Finally, the investigator seeks to delineate specific neural circuits contributing to PD subtypes and validate biological markers. As a future step, the investigator will apply what is learned from the training and research aims described herein to examine the molecular genetics associated with PD typologies and apply acquired knowledge regarding PD subtypes to the examination of treatment response, with the goal of improving treatment efficacy. The proposed training will provide the investigator with a unique skill base and experience needed to conduct innovative, high quality psychiatric genetic research as an independent clinical investigator.

描述（由申请人提供）：该K01指导的研究科学家发展奖提议提供精神病和分子遗传学的高级研究培训，研究重点是恐慌症（PD）。肯尼斯·肯德勒（Kenneth S.该培训将在弗吉尼亚联邦大学的弗吉尼亚精神病学和行为遗传学研究所举行，该研究所为进行培训和研究提供了丰富而刺激的环境。该应用程序概述了一项培训计划，该计划将使Roberson-Nay博士能够将她以前的焦虑症研究和神经影像学经验与精神病和分子遗传学方面的新获得技能相结合。提出的培训目标将在五个领域提供进一步的指导和指导：a。流行病学/遗传流行病学，b。）缔合方法，c。）分子遗传学，d。）呼吸生理学和神经生理学，以及e。）负责研究。该奖项的研究重点是PD，这是一种令人衰弱的精神疾病，其特征是意外的，反复的恐慌发作。对于她的研究目的，研究人员将采用多方法研究PD类型的研究，其中她将检查PD中的表型差异，以识别临床上相关和有意义的亚型。这些结果将用于指导多模式的方法检查PD类型。也就是说，研究者将检查危险因素和PD类型的进展，并试图识别赋予其脆弱性的机制（即遗传，环境）。最后，研究人员试图描述有助于PD亚型并验证生物学标记的特定神经回路。作为将来的一步，研究人员将应用从培训和研究目的中学到的内容来检查与PD类型相关的分子遗传学，并将有关PD亚型的获得的知识应用于治疗反应的检查，目的是提高治疗功效。拟议的培训将为研究人员提供独特的技能基础和经验，以作为独立的临床研究者进行创新的高质量精神遗传研究。