COBRE: UMMC: NEUROBEHAV EFFECTS OF EARLY EXPOSURE TO PSYCHOTHERAPEUTIC AGENTS

COBRE：UMMC：早期接触精神治疗药物的神经行为影响

• 批准号: 7381913
• 负责人: IAN A. PAUL
• 金额: $ 4.33万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381913
• 关键词: COBRE; UMMC; NEUROBEHAV; EFFECTS; EARLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is focused on the effects of early exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants on brain development and behavior. SSRIs are the pharmacotherapy of choice for pregnant and nursing mothers and recent studies have demonstrated that the fetus and nursing infant are exposed to drug concentrations similar to those of the mother. Little is known about the long-term neurobiological effects of early SSRI exposure however, recent studies indicate that such exposure may have lasting increases in irritability and impairment of fine motor behavior and pain sensitivity in humans. In rodent models of early antidepressant exposure, lasting impairment of male sexual behavior and aggressive response has been noted. We have recently demonstrated that the behavioral effects of early antidepressant exposure are also produced by highly selective SSRIs. Moreover, such exposure results in permanent reductions in the expression of tryptophan hydroxylase and the serotonin transporter which are critical proteins regulating serotonergic circuits

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。这项研究的重点是早期接触选择性血清素再摄取抑制剂（SSRI）抗抑郁药对大脑发育和行为的影响。 SSRIs 是孕妇和哺乳期母亲的首选药物治疗，最近的研究表明，胎儿和哺乳期婴儿接触的药物浓度与母亲相似。人们对早期接触 SSRI 的长期神经生物学影响知之甚少，但最近的研究表明，这种接触可能会持续增加人类的烦躁性，并损害精细运动行为和疼痛敏感性。在早期接触抗抑郁药物的啮齿动物模型中，已注意到男性性行为和攻击性反应的持久损害。我们最近证明，早期抗抑郁药物暴露的行为效应也是由高选择性 SSRI 产生的。此外，这种暴露会导致色氨酸羟化酶和血清素转运蛋白的表达永久减少，它们是调节血清素能回路的关键蛋白质