S-MARS

火星火星

• 批准号: 7381016
• 负责人: REBECCA DIN-DZIETHAM
• 金额: $ 13.68万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381016
• 关键词: MARS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major objective of this project is to characterize the abnormalities of vascular gene expression occurring in early, subclinical stages of vascular disease, as assessed by large artery function, in adult obesity and to assess its correlates and the potential pathobiological mediating pathways between vascular dysfunction and vascular gene expression. While compelling evidence indicates that genetic and other biological factors predispose to obesity and hypertension, these common, co-occurring disorders likely reflect a complex interplay between biological factors and the psychosocial and cultural environment. Taken together, this series of studies will be among the first to link changes in human vascular mRNA expression profiles with physiologic alterations in vascular function and obesity. Overall, it is anticipated that these experiments will provide new insights into the molecular basis of vascular stiffness and endothelial dysfunction in high-risk AfricanAmerican obese subjects.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目的一个主要目的是表征在早期的血管疾病亚临床阶段发生的血管基因表达的异常，如大动脉功能，成人肥胖症所评估的，并评估其相关性及其潜在病原体介导途径之间的潜在病原体介导途径血管基因表达。尽管令人信服的证据表明，遗传和其他生物学因素易于肥胖和高血压，但这些常见的，同时发生的疾病可能反映了生物学因素与心理社会和文化环境之间的复杂相互作用。综上所述，这一系列研究将是第一个将人血管mRNA表达谱变化与血管功能和肥胖症的生理改变联系起来的研究之一。总体而言，预计这些实验将提供有关高危非洲人肥胖受试者血管刚度和内皮功能障碍的分子基础的新见解。