Trends in blood pressure in relation to obesity

与肥胖相关的血压趋势

• 批准号: 6850005
• 负责人: REBECCA DIN-DZIETHAM
• 金额: $ 7.1万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-05 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6850005
• 关键词: African American; adipose tissue; adolescence (12-20); antioxidants; blood pressure; body composition; caucasian American; child (0-11); human data; hypertension; obesity

DESCRIPTION (provided by applicant): Hypertension remains a major public health problem. Several studies support the theory that the roots of essential hypertension may extend back to childhood. With obesity reaching epidemic proportions and youth obesity being one of the strongest predictor of young adulthood hypertension, little empirical information is available on secular changes in the prevalence of hypertension in youth. Current data on secular trends of blood pressure in this age group are sparse and inconsistent. The proposed 2-year secondary analysis of the US national survey data addresses this issue with the following aims: 1. (a) To describe the trends in age-adjusted mean systolic blood pressure, diastolic blood pressure, and pulse pressure and the age-adjusted prevalence of hypertension for all boys and girls, 6-17 years of age; (b) To describe these trends separately for African-American and White participants. 2. To evaluate whether these trends are modified or partially explained by obesity, as assessed by body-mass-index, the ratio of triceps over subscapular skinfold thickness, and percent body fat. 3. To evaluate whether the correlation of blood pressure with obesity is modified or explained by dietary and blood antioxidant levels. The study population will consist of 6 to 17 year old participants in NHES II through NHANES IV-Phase I Surveys (1963-2000). These surveys were conducted by the National Center for Health Statistics on a nationwide probability sample, based on a complex multistage sample design to provide national estimates of health and nutritional status of the civilian noninstitutionalized population of the United States aged 2 months and older. Weighted analyses will be used to obtain valid estimates. This study has the potential to contribute new knowledge with respect to the national burden of hypertension in youth in the face of increasing youth obesity. Studies may suggest an inflammatory etiologic component associated with hypertension, which starts in youth in obese children. Research findings would lead to more refined mechanistic studies for ultimately better tailored interventions.

描述（由申请人提供）：高血压仍然是一个重大的公共卫生问题。几项研究支持这样的理论，即基本高血压的根源可能会延伸到童年。由于肥胖的流行比例，青年肥胖是年轻成年期高血压的最强预测指标之一，几乎没有关于年轻人高血压患病率的世俗变化的经验信息。当前有关该年龄段血压世俗趋势的数据稀疏且不一致。拟议的对美国国家调查数据的2年次要分析以以下目的解决了这一问题： 1。（a）描述年龄调整后的平均收缩压，舒张压和脉搏压力以及所有男孩和女孩的高血压患病率，6-17岁； （b）为非裔美国人和白人参与者分别描述这些趋势。 2。为了评估这些趋势是通过肥胖来修改还是部分解释，如人体质量索引评估，三头肌比肩cap骨皮肤折叠厚度的比例和体内脂肪百分比。 3。评估血压与肥胖的相关性是通过饮食和血液抗氧化剂水平修饰或解释的。 研究人群将由NHES II的6至17岁参与者通过NHANES IV期I调查（1963-2000）组成。这些调查是由国家卫生统计中心对全国概率样本进行的，基于复杂的多阶段样本设计，以提供全国性的2个月及以上的美国平民非机构化人口的健康和营养状况。加权分析将用于获得有效的估计。 这项研究有可能在面对年轻人肥胖的日益增加的青年中对青年的全国性高血压负担贡献新知识。研究可能表明与高血压相关的炎症病因学成分始于肥胖儿童的青年。研究结果将导致更精致的机械研究，以最终获得更好的量身定制干预措施。