LOW DOSE INHALED NITRIC OXIDE TO PREVENT CHRONIC LUNG DISEASE IN PRETERM INFANTS

低剂量吸入一氧化氮预防早产儿慢性肺病

• 批准号: 7378042
• 负责人: RICHARD JOHN MARTIN
• 金额: $ 0.93万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378042
• 关键词: LOW; DOSE; INHALED; NITRIC; OXIDE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, randomized, blinded clinical trial to investigate whether low-dose inhaled nitric oxide administered to preterm infants of 500-1250 g birth weight who continue to require mechanical ventilation or continuous position airway pressure at 7 days of age will increase survival without chronic lung disease at 36 weeks postmenstrual age. The study will also evaluate the safety of this therapy by assessing toxicity and assessing neurodevelopmental outcome through two years of age. The enrollment goal is 585 infants over 4 years. Subjects have two outpatient visits at 9-12 months corrected age and 22-26 months corrected age for ongoing evaluation of the baby's growth and development.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这是一项多中心，随机，盲目的临床试验，可调查对500-1250 g出生体重的早产儿给药的低剂量吸入硝酸氧化物，这些氧化物是否继续需要机械通气或7天的持续位置气道在7天内持续位置气道会增加生存率，而无需在36周的年龄年龄的36周内增加生存率。该研究还将通过评估毒性和评估两岁的神经发育结果来评估该疗法的安全性。入学目标是4年内585名婴儿。受试者在9-12个月的校正年龄和22-26个月的校正年龄进行两次门诊就诊，以持续评估婴儿的生长和发育。