WHITE MATTER ABNORMALITIES IN BIPOLAR ADOLESCENTS

双相情感障碍青少年的白质异常

• 批准号: 7377117
• 负责人: VIVIAN KAFANTARIS
• 金额: $ 0.77万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377117
• 关键词: WHITE; MATTER; ABNORMALITIES; BIPOLAR; ADOLESCENTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to use MRI, Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (MRS) to determine if there are significant differences in white matter characteristics between 25 clinically stabilized bipolar-manic or mixed phase adolescents and 25 age, gender and IQ-matched healthy volunteers. We hypothesize that, in comparison to healthy controls, bipolar adolescents (a) will be more likely to have confluent white matter hyperintensities; (b) will exhibit decreased integrity of white matter tracts as evidenced by significantly lower anisotropy on DTI scanning; and (c) will have lower N-acetyl aspartate (NAA) levels in white matter based on spectroscopy. We also hypothesize that, in comparison to healthy controls, our adolescent bipolar subjects will have poor global development of the brain as evidenced by: (a) widespread cortical gray matter deficits, most pronounced in the prefrontal area, and (b) enlarged lateral ventricles

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究建议使用MRI，扩散张量成像（DTI）和磁共振光谱（MRS）来确定25种临床稳定的双极式或混合相青少年和25岁年龄，性别，性别和IQ匹配的健康志愿者之间的白质特征在白质特征之间存在显着差异。我们假设与健康对照组相比，双极青少年（a）更有可能具有汇合的白质超强度。 （b）将表现出降低的白质区的完整性，这是由于DTI扫描的各向异性明显降低所证明的； （c）基于光谱法的白质中的N-乙酰基酸天冬氨酸水平较低。我们还假设，与健康对照组相比，我们的青春期双极受试者的全球大脑发育不良，如下所证明：（a）普遍存在的皮质灰质缺陷，在前侧面最明显，（b）侧心肿大。