Amygdala and Prefrontal Control of the Rhinal Cortices

杏仁核和鼻皮质的前额叶控制

• 批准号: 7109535
• 负责人: ELIZABETH P BAUER
• 金额: $ 4.88万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109535
• 关键词: amygdala; arousal; behavioral /social science research tag; brain electrical activity; cats; electroencephalography; emotions; entorhinal cortex; gamma aminobutyrate; injection /infusion; memory; neural information processing; neuropharmacology; neurotransmitter antagonist; postdoctoral investigator; prefrontal lobe /cortex; single cell analysis; stereotaxic techniques

DESCRIPTION (provided by applicant): The rhinal cortices play a critical role in declarative memory and constitute the main route for impulse traffic between the hippocampus and cortex. However, physiological data suggests that the rhinal cortices are not a passive relay station; neocortical and entorhinal inputs are transmitted with a low probability. The goal of the research described here is to assess whether and how the inhibitory mechanisms that limit impulse propagation through the rhinal cortices are lifted. One possibility is that this could occur during emotionally arousing conditions, when declarative memory is generally enhanced. Both the amygdala and medial prefrontal cortex project heavily to the rhinal cortices, and both are implicated in the facilitation of memory by emotions. Both extracellular and intracellular recordings in vivo in anesthetized cats will assess the ability of the amygdala and medial prefrontal cortex to facilitate impulse transfer through the rhinal cortices.

描述（申请人提供）：鼻皮质在陈述性记忆中起着至关重要的作用，并构成海马体和皮质之间冲动交通的主要路线。然而，生理数据表明，鼻皮质并不是一个被动的中继站；它是一个被动的中继站。新皮质和内嗅输入的传输概率很低。这里描述的研究的目的是评估限制冲动通过鼻皮质传播的抑制机制是否以及如何解除。一种可能性是，这种情况可能发生在情绪激动的情况下，此时陈述性记忆普遍增强。杏仁核和内侧前额叶皮层都大量投射到鼻皮质，两者都与情绪促进记忆有关。麻醉猫体内的细胞外和细胞内记录将评估杏仁核和内侧前额叶皮层促进冲动通过鼻皮质传递的能力。