Neural Mechanisms for Emotion in the Amygdala

杏仁核情绪的神经机制

• 批准号: 7058163
• 负责人: KEVIN M SPITLER
• 金额: $ 3.37万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2007-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058163
• 关键词: Macaca mulatta; amygdala; arousal; behavioral /social science research tag; emotions; heart rate; memory; neural information processing; neuropsychological tests; neuropsychology; predoctoral investigator; psychophysiology; visual stimulus

DESCRIPTION (provided by applicant): The fast pace and increased psycho-social stress of life in developed countries is correlated with a large increase in affective disorders. Thirty-seven million Americans suffer from a form of anxiety or depression (Narrow et al., 1998; Robins and Regier, 1990). Conventional treatments are only partially successful in combating these disorders because the neural mechanisms underlying normal and pathological emotion are not fully understood. One well-established finding is that the amygdala, a cluster of deep brain nuclei, is a key structure in the complex brain circuit of emotions. In this circuit, incoming signals from all sensory modalities converge in the amygdala where they are converted into modulatory signals directed at memory structures and to autonomic centers of emotional response. The goal of this project is to use neurophysiological techniques to elucidate the neural mechanisms that underlie the differentiation of emotional stimuli, the formation of emotional memories, and the orchestration of somatic and autonomic responses in the primate amygdala

描述（由申请人提供）：发达国家生活的快节奏和社会心理压力的增加与情感障碍的大量增加有关。三千七百万美国人患有某种形式的焦虑或抑郁（Narrow 等，1998；Robins 和 Regier，1990）。常规治疗在对抗这些疾病方面仅取得部分成功，因为正常和病理情绪背后的神经机制尚未完全了解。一项公认的发现是，杏仁核是一组深部大脑核团，是复杂的大脑情绪回路中的关键结构。在这个回路中，来自所有感觉方式的输入信号汇聚到杏仁核，在那里它们被转换成针对记忆结构和情绪反应自主中心的调制信号。该项目的目标是利用神经生理学技术来阐明灵长类杏仁核情绪刺激分化、情绪记忆形成以及躯体和自主反应的编排背后的神经机制。