Austism and Related Disorders: Development and Outcome

自闭症和相关疾病：发展和结果

• 批准号: 7499032
• 负责人: FRED Robert Volkmar
• 金额: $ 111.53万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499032
• 关键词: Austism; Related; Disorders; Development; Outcome

DESCRIPTION (provided by applicant): This application requests five years of continued support for an ongoing, multidisciplinary program of research on autism and related developmental disorders. The proposed work represents the evolution of the program project reflecting an increased focus on autism and related disorders. This application builds on important resources and research programs available at Yale. The broad theme that unifies this research program is the focus on understanding mechanisms of dysfunction in autism, and related conditions as they relate to development and outcome. The focus of the grant is on integrating advances in neuropsychology, developmental psychopathology, neuroscience and genetics into understanding the clinical manifestations, which in turn are studied in relation to specific neurodevelopmental processes and risk factors. Objectives include: 1) elucidating the earliest manifestations of autism from birth to 2 years through the prospective study of a large cohort of infants with a sibling who has autism; 2) identifying predictors of outcome and clarify phenotypic variation in autism in a large group of school aged children, who were originally diagnosed with a pervasive developmental disorder at 2 years of age using a longitudinal design that will map trajectories across multiple domains of development; 3) clarifying mechanisms in the development and expression of conversational pragmatics and prosody in high functioning individuals with ASD through studies using emerging technologies to examine conversational behaviors in greater depth and lay the foundation for developmental measures that can be used in clinical settings. In addition to these three projects three core resources are proposed and include: A) Administrative, B) Assessment C) Statistics & Research Design. This application brings together existing and new expertise, infrastructure and resources focused on diagnosis, early detection, causes, and treatment of autism. The work proposed is highly interdisciplinary drawing on both basic and clinical sciences and innovative research designs and state-of-the-art technologies. This work brings together, behavioral, biomedical, and clinical science investigators into a transdisciplinary program of research on autism.

描述（由申请人提供）：本申请要求对正在进行的自闭症和相关发育障碍的持续多学科研究计划进行五年的持续支持。拟议的工作代表了计划项目的演变，反映出对自闭症和相关疾病的关注越来越多。该应用程序建立在耶鲁大学可用的重要资源和研究计划的基础上。统一该研究计划的广泛主题是理解自闭症功能障碍的机制，以及与发展和结果有关的相关条件。该赠款的重点是整合神经心理学，发育心理病理学，神经科学和遗传学的进步，以理解临床表现，而这些表现又是根据特定的神经发育过程和风险因素进行研究的。目的包括：1）通过对大量的婴儿队兄弟姐妹进行自闭症的群体，阐明了从出生到2年的自闭症的最早表现； 2）确定一大群学校老年儿童的自闭症的预测因素并阐明自闭症的表型变异，他们最初使用纵向设计在2岁时被诊断出患有普遍性发育障碍，该纵向设计将在多个发育领域绘制轨迹； 3）通过使用新兴技术进行更深入的对话行为的研究，阐明了在高功能的ASD中的对话性实用主义和韵律中的开发和表达机制，并为可以在临床环境中使用的发育措施奠定了基础。除这三个项目外，还提出了三个核心资源，包括：a）行政，b）评估c）统计与研究设计。该应用程序汇集了针对诊断，早期检测，原因和自闭症治疗的现有和新的专业知识，基础设施和资源。提出的工作是关于基础科学和创新研究设计以及最先进技术的高度跨学科绘制的。这项工作将行为，生物医学和临床科学研究者汇集到了自闭症研究的跨学科研究计划。