A QUANTITAVE TEST OF ON-ORBIT EXERCISE COUNTERMEASURES

在轨演习对策的定量测试

• 批准号: 7377716
• 负责人: PETER Robert CAVANAGH
• 金额: $ 69.93万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377716
• 关键词: QUANTITAVE; TEST; ORBIT; EXERCISE; COUNTERMEASURES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bedrest is an excellent analog for the study of on-orbit musculoskeletal changes that occur during long-duration spaceflight. Our novel approach involves quantifying typical daily loads to the lower extremities in selected free-living volunteer subjects who are not habitual exercisers and planning individual exercise prescriptions based on daily load stimulus theory. Subjects will then be randomized to control or exercise groups and confined to 6-degree head-down bedrest in the General Clinical Research Center (GCRC) at the Cleveland Clinic Foundation (CCF) for 12 weeks. During this time, the exercise group will undergo individualized daily exercise programs in the unique Zero Gravity Locomotion Simulator (ZLS) at CCF designed to replace their daily mechanical load stimulus experienced during free living. A treadmill and a resistance-exercise device similar to those available on the International Space Station will be used for exercise. DXA, MRI, and QCT scans will be conducted at the start and end of bedrest to assess variations in bone mineral density, changes in muscle volume, and regional changes (cortical vs. trabecular) in bone. DXA scans will also be conducted at week 8 of bedrest. Strength measurements will be collected pre- and post-bedrest, and urinary and serum markers of bone resorption and formation will also be assessed. Dietary intake sufficient to maintain constant body weight with a balanced intake of macro- and micronutrients will be planned and supervised by a registered dietician, and a GCRC physician will be available 24 hr/day to attend to any medical needs. A rehabilitation program will be offered to subjects in the 8 weeks following bedrest. The proposed experiment should provide a categorical answer to the question of whether intermittent load replacement can adequately protect the musculoskeletal system against hypokinetic osteopenia and muscle atrophy and may open a new era in individualized exercise countermeasure planning.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 Bedrest是研究长期太空飞行期间发生的轨道肌肉骨骼变化的绝佳类似物。我们的新方法涉及将典型的每日载荷量化为选定的自由生活志愿者的下肢，这些志愿者不是习惯性锻炼者，并根据日常负载刺激理论计划单个运动处方。然后，受试者将被随机分配给对照组或运动组，并局限于克利夫兰诊所基金会（CCF）的一般临床研究中心（GCRC）中的6度降低床上，持续12周。在此期间，锻炼组将在CCF处的独特的零重力运动模拟器（ZLS）中进行个性化的日常锻炼程序，旨在替代自由生活中经历的日常机械负荷刺激。跑步机和类似于国际空间站可用的设备将用于锻炼。 DXA，MRI和QCT扫描将在床架的开头和结尾进行，以评估骨骼矿物质密度的变化，肌肉体积的变化以及骨骼中的区域变化（皮质与小梁）。 DXA扫描也将在Bedrest的第8周进行。还将评估骨吸收和形成的尿液和血清标志物，还将评估强度测量值。饮食摄入量足以维持恒定的体重，并通过注册营养师计划和监督宏观和微量营养素的均衡摄入量，而GCRC医生将24小时/天提供GCRC医生，以满足任何医疗需求。在卧床之后的8周内，将向受试者提供康复计划。拟议的实验应为是否可以充分保护肌肉骨骼系统免受肌肉骨骼的骨质骨质减少和肌肉萎缩，并可能在个性化的运动对策计划中开放一个新时代。