FACTORS REGULATING HUMAN SKELETAL MUSCLE ATROPHY (FKA A QUANTITATIVE TEST

调节人类骨骼肌萎缩的因素（FKA 定量测试）

• 批准号: 7377724
• 负责人: PETER Robert CAVANAGH
• 金额: $ 0.09万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377724
• 关键词: FACTORS; REGULATING; HUMAN; SKELETAL; MUSCLE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. GCRC Resource Utilization: Inpatient Stays Nursing Support Ancillary Support ABSTRACT: Bedrest is an excellent analog for the study of on-orbit musculoskeletal changes that occur during long-duration spaceflight. Our novel approach involves quantifying typical daily loads to the lower extremities in selected free-living volunteer subjects who are not habitual exercisers and planning individual exercise prescriptions based on daily load stimulus theory. Subjects will then be randomized to control or exercise groups and confined to 6-degree head-down bedrest in the General Clinical Research Center (GCRC) at the Cleveland Clinic Foundation (CCF) for 12 weeks. During this time, the exercise group will undergo individualized daily exercise programs in the unique Zero Gravity Locomotion Simulator (ZLS) at CCF designed to replace their daily mechanical load stimulus experienced during free living. A treadmill and a resistance-exercise device similar to those available on the International Space Station will be used for exercise. DXA, MRI, and QCT scans will be conducted at the start and end of bedrest to assess variations in bone mineral density, changes in muscle volume, and regional changes (cortical vs. trabecular) in bone. DXA scans will also be conducted at week 8 of bedrest. Strength measurements will be collected pre- and post-bedrest, and urinary and serum markers of bone resorption and formation will also be assessed. Dietary intake sufficient to maintain constant body weight with a balanced intake of macro- and micronutrients will be planned and supervised by a registered dietician, and a GCRC physician will be available 24 hr/day to attend to any medical needs. A rehabilitation program will be offered to subjects in the 8 weeks following bedrest. The proposed experiment should provide a categorical answer to the question of whether intermittent load replacement can adequately protect the musculoskeletal system against hypokinetic osteopenia and muscle atrophy and may open a new era in individualized exercise countermeasure planning.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。 GCRC 资源利用：住院护理支持辅助支持 摘要：卧床休息是研究长期太空飞行期间在轨肌肉骨骼变化的绝佳模拟。我们的新颖方法包括量化选定的不习惯锻炼的自由生活志愿者受试者下肢的典型每日负荷，并根据每日负荷刺激理论规划个人运动处方。然后，受试者将被随机分为对照组或运动组，并在克利夫兰诊所基金会 (CCF) 的普通临床研究中心 (GCRC) 中进行 6 度头低位卧床休息 12 周。在此期间，锻炼小组将在 CCF 独特的零重力运动模拟器 (ZLS) 中接受个性化的日常锻炼计划，该模拟器旨在取代他们在自由生活期间经历的日常机械负荷刺激。锻炼时将使用与国际空间站上类似的跑步机和阻力锻炼设备。将在卧床休息开始和结束时进行 DXA、MRI 和 QCT 扫描，以评估骨矿物质密度的变化、肌肉体积的变化以及骨骼的区域变化（皮质与小梁）。 DXA 扫描也将在卧床休息的第 8 周进行。将在卧床休息前和卧床休息后收集力量测量值，并且还将评估骨吸收和形成的尿液和血清标志物。注册营养师将计划和监督足以维持恒定体重的饮食摄入量，并均衡摄入大量营养素和微量营养素，并且 GCRC 医生将每天 24 小时为您服务，以满足任何医疗需求。卧床休息后 8 周内将为受试者提供康复计划。所提出的实验应该为间歇性负荷替代是否能够充分保护肌肉骨骼系统免受低运动性骨质减少和肌肉萎缩的问题提供明确的答案，并可能开启个性化运动对策规划的新时代。