Defining Translational Approaches for the Image-based Detection of Prenatal Alcohol Exposure

定义基于图像的产前酒精暴露检测的转化方法

• 批准号: 10470409
• 负责人: Michael Suttie
• 金额: $ 23.94万
• 依托单位: UNIVERSITY OF OXFORD
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470409
• 关键词: 3-Dimensional; Address; Adolescent; Adult; Age; Agreement; Alcohols; Assessment tool; Automation; Brain; Categories; Cellular Phone; Cephalic; Child; Clinic; Clinical; Clinical assessments; Cognitive; Collaborations; Communities; Computer software; Corpus Callosum; Data; Data Management Resources; Data Set; Devices; Diagnosis; Discrimination; Elements; Ensure; Ethnic Origin; Evaluation; Face; Feedback; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal alcohol effects; Fissural; Goals; Image; Image Analysis; Imaging Device; Impaired cognition; Individual; Infant; Intervention; Intervention Studies; Length; Life; Lip structure; Literature; Longevity; MRI Scans; Machine Learning; Mandible; Measurement; Methodology; Methods; Micrognathism; Monoclonal Antibody R24; Morphology; Neonatal; Neurocognitive; Ocular orbit; Online Systems; Orbital separation excessive; Outcome; Output; Parents; Population; Request for Applications; Research; Resources; Screening procedure; Secondary to; Sensitivity and Specificity; Sex Differences; Shapes; Smoking; Surface; System; Tablets; Techniques; Technology; Testing; Thinness; Three-Dimensional Image; Three-Dimensional Imaging; Time; Training; Translating; Trees; Ultrasonography; Validation; Variant; Work; alcohol consumption during pregnancy; alcohol exposure; base; brain morphology; brain shape; clinical application; clinical diagnosis; clinical translation; cloud platform; cognitive testing; comparative; cost; deep learning; experience; imaging detection; improved; midfacial hypoplasia; neurocognitive test; offspring; polysubstance use; recruit; relating to nervous system; screening; sex; sexual dimorphism; skills; tool; trait; translational approach; ultrasound

As a constituent component of CIFASD5, this project will focus on improving the identification of individuals with prenatal alcohol exposure (PAE), across the lifespan, with the primary goal of translation for clinical application. We target two main categories outlined in the Request for Application (RFA) 1. To identify FASD cases early and accurately, and 2. To expand and translate basic and mechanistic understandings of the effects of PAE. To address these topics, we aim to improve the accuracy and reliability of the clinical recognition of FASD, controlling for the influence of sex, co- exposures, and age. We seek to understand better how neurocognitive and facial morphology are correlative and covariant in FASD and exploit this relationship to improve screening accuracy. Previously, we have implemented methods and associated software for analyzing face shape and face - brain-cognitive relationships to detect the effects of PAE. In doing so, we have created an effective toolkit to automatically and objectively identify cardinal and subtle PAE-associated facial dysmorphism across the FASD spectrum. It is now a priority to refine and optimize our methods, utilizing low-cost 3D imaging devices to validate and distribute to the clinical community. To accomplish our goals, we propose to follow specific aims: 1. Explore the impact of factors secondary to alcohol exposure that may influence facial morphology; 2. Detect facial, cranial, and neural effects of prenatal alcohol exposure across the lifespan; 3. Develop, test, and validate automated methods for FASD screening, integrating neurocognitive assessment tools and distributing to the clinical community. Achieving aims 1 and 2 will dramatically refine FASD recognition by understanding the factors secondary to alcohol that may influence outcomes across the lifespan. Successful demonstration of aim 2 will achieve the earliest possible diagnosis enabling further research and feedback for intervention studies and also focus on recognizing traits in adults - a population significantly underreported in the literature. Ultimately, aim 3 encompasses the primary goal of the project, developing, testing, and validating multi-domain screening tools that assist with clinical identification. We will work closely with consortium partners who will recruit subjects and provide facial images and neurocognitive assessment data (U01: Chambers; U01: Coles & Weinberg; U01: Wozniak; U01: DiClemente; U01: Petrenko). Particularly close collaboration is required for the face-neurocognitive analysis, where we will integrate and combine facial and neurocognitive screening tools (U01: Mattson). We will rely on research resources for data management (R24: Wetherill) and to validate screening tools and gain clinical feedback (R24: Del Campo).

作为CIFASD5的组成部分，该项目将着重于改进识别 在整个生命周期中，患有产前酒精暴露（PAE）的个体，其主要目标是 临床应用的翻译。我们针对申请请求中概述的两个主要类别 （RFA）1。早日和准确地识别FASD案例，以及2。扩展和翻译基本和翻译 对PAE影响的机械理解。为了解决这些主题，我们旨在改善 FASD临床识别的准确性和可靠性，控制性别的影响 暴露和年龄。我们试图更好地了解神经认知和面部形态 在FASD中相关和协变量，并利用这种关系以提高筛选准确性。 以前，我们已经实施了用于分析面部形状和面部的方法和相关软件 - 脑认知关系以检测PAE的影响。这样，我们创造了一个有效的 工具包可以自动，客观地识别基本和微妙的PAE相关的面部畸形 跨越FASD频谱。现在，使用低成本来完善和优化我们的方法已成为优先事项 3D成像设备以验证和分发给临床社区。为了实现我们的目标，我们 建议遵循特定目的： 1。探索可能影响面部形态的酒精暴露的因素的影响； 2。检测整个生命周期产前酒精暴露的面部，颅骨和神经作用； 3。开发，测试和验证用于FASD筛查的自动化方法，整合神经认知 评估工具并分发给临床社区。 实现目标1和2将通过了解因素来大大提高FASD的识别 其次是酒精，可能会影响整个生命周期的结果。成功的演示 AIM 2将实现最早的诊断，从而实现进一步的研究和反馈 干预研究，还专注于认识成年人的特征 - 人口显着 在文献中报道了不足。最终，AIM 3涵盖了该项目的主要目标， 开发，测试和验证有助于临床识别的多域筛选工具。 我们将与财团合作伙伴紧密合作，他们将招募主题并提供面部图像和 神经认知评估数据（U01：Chambers; U01：Coles＆Weinberg; U01：Wozniak; U01： 迪肯； U01：Petrenko）。面部神经认知需要特别紧密的协作 分析，我们将在其中整合并结合面部和神经认知筛查工具（U01： 马特森）。我们将依靠研究资源进行数据管理（R24：Wetherill）并验证 筛查工具并获得临床反馈（R24：DEL Campo）。