RADIOGRAPHIC TEXTURE DURING OSTEOPOROSIS THERAPY

骨质疏松症治疗期间的放射线纹理

• 批准号: 7378608
• 负责人: TAMARA J VOKES
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378608
• 关键词: bone; bone density; calcium; osteoporosis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project aims to determine whether a novel method of assessing bone structure through computerized analysis of digitized bone radiographs (texture analysis) improves our ability to diagnose bone fragility and follow response to treatment for osteoporosis. The study proposed in this CRC application will examine whether texture analysis changes during antiresorptive therapy in a way that can be used clinically for assessing treatment response. Central bone density of the lumbar spine and the femoral neck, peripheral bone density of the heel, texture analysis of the digitized images of os calcis and biochemical markers of bone turnover will be examined every 6 months for 2 years in 20 women receiving calcium supplementation and Alendronate ( 70 mg once weekly) and in 20 control women receiving only calcium supplements. The results of this study will be used to determine whether antiresorptive therapy influences texture analysis, and to determine if combined texture analysis and heel BMD can accurately assess response to antiresorptive therapy and do so as well as currently used methods including central densitometry and/or measurement of biochemical markers.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该项目旨在确定一种通过数字化骨射线照片的计算机分析（纹理分析）来评估骨结构的新方法是否可以提高我们诊断骨脆性和跟踪骨质疏松症治疗反应的能力。该 CRC 申请中提出的研究将检查纹理分析在抗吸收治疗期间是否会发生变化，从而可在临床上用于评估治疗反应。研究人员将在 20 名接受补钙和治疗的女性中，每 6 个月检查一次腰椎和股骨颈的中央骨密度、足跟周围的骨密度、钙骨数字化图像的纹理分析以及骨转换的生化标记物，为期 2 年。阿仑膦酸钠（70 毫克每周一次）和 20 名仅接受钙补充剂的对照女性。这项研究的结果将用于确定抗吸收治疗是否影响纹理分析，并确定纹理分析和足跟 BMD 相结合是否可以准确评估抗吸收治疗的反应，以及目前使用的方法，包括中心密度测定和/或测量的生化标记物。