Clinical Utility of Texture Analysis in Osteoporosis

纹理分析在骨质疏松症中的临床应用

• 批准号: 6901044
• 负责人: TAMARA J VOKES
• 金额: $ 12.34万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901044
• 关键词: biomarker; bone density; bone fracture; bone imaging /visualization /scanning; bone metabolism; calcium; clinical research; densitometry; enzyme linked immunosorbent assay; human subject; joints; noninvasive diagnosis; osteoporosis; patient oriented research; photon absorptiometry; radiography; skeletal disorder chemotherapy; skeletal pharmacology; substantia spongiosa; vitamin D

DESCRIPTION (provided by applicant): The enclosed proposal outlines the multidisciplinary training and research plans for Dr. Tamara Vokes for K23 funding. Dr. Vokes plans an integrated and intensive training program in the area of radiographic texture analysis and its application to osteoporosis research and clinical practice. Training will include courses in medical imaging and image processing which is part of Graduate Programs in Medical Physics offered through the Department of Radiology, and advanced courses in statistics and epidemiology offered through the Department of Health Studies. In addition, training and development will entail intensive mentoring by Dr. Murray Favus and Dr. Maryellen Giger, including weekly meetings, informal discussions and review of manuscripts and grants. Additionally, campus seminars and attendance and presentations at national meetings are integral components of Dr. Vokes' program. With this additional training and mentored research experience, Dr. Vokes will be in a position to develop an independent research program in the area of clinical application of non-invasive assessment of bone structure. The research component of the proposal tests the hypothesis that radiographic texture analysis performed on high-resolution calcaneal images obtained by a portable densitometer can significantly improve the assessment of bone fragility. Currently the only clinical test used for assessment of fragility is bone mineral density (BMD), which assesses bone quantity but not its quality. The latter is believed to be related to trabecular structure or microarchitecture and cannot be easily assessed by currently available modalities. Texture analysis is one of the methods being investigated for non-invasive evaluation of trabecular structure. In Specific Aim 1, it will be determined whether detection of bone fragility in vivo is significantly improved by texture analysis. In Specific Aim 2, it will be determined whether texture analysis changes during 2 years of anti-resorptive therapy and whether it could be used for evaluating therapeutic response. Following the successful completion of the proposed studies, prospective evaluation of texture analysis will be undertaken in larger populations and in different forms of metabolic bone disease.

描述（由申请人提供）： 封闭式提案概述了塔玛拉（Tamara）博士（K23）资助的多学科培训和研究计划。 Vokes博士计划在放射学纹理分析领域及其在骨质疏松研究和临床实践中的应用方面进行集成而密集的培训计划。培训将包括医学成像和图像处理课程，这是放射学系提供的医学物理学研究生课程的一部分，以及通过卫生研究部提供的统计和流行病学的高级课程。此外，培训和发展还需要由Murray Favus博士和Maryellen Giger博士进行密集的指导，包括每周会议，非正式讨论和审查手稿和赠款。此外，校园研讨会以及参加全国会议上的出勤和演讲是Vokes博士计划的组成部分。凭借这一额外的培训和指导的研究经验，Vokes博士将有能力在骨骼结构无创评估的临床应用领域制定独立的研究计划。该提案的研究成分检验了以下假设：对通过便携式密度计获得的高分辨率跟骨图像进行的放射线纹理分析可以显着改善骨骼脆弱性的评估。目前，用于评估脆弱性的唯一临床测试是骨矿物质密度（BMD），它评估了骨骼数量，但不能评估其质量。后者被认为与小梁结构或微观结构有关，因此无法通过当前可用的方式轻松评估。纹理分析是研究小梁结构的非侵入性评估的方法之一。在特定的目标1中，将确定通过纹理分析可显着改善体内骨脆弱性的检测。在特定的目标2中，将确定纹理分析在2年的抗高压疗法中是否会发生变化，以及是否可以用于评估治疗反应。成功完成拟议的研究后，将在较大的人群和不同形式的代谢骨病中对纹理分析进行前瞻性评估。