NASAL HIGH-FREQUENCY VENTILATION FOR PREMATURE INFANTS

早产儿经鼻高频通气

• 批准号: 7377089
• 负责人: Tarah Trinity Colaizy
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377089
• 关键词: NASAL; FREQUENCY; VENTILATION; PREMATURE; INFANTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prolonged mechanical ventilation is frequently needed to treat respiratory insufficiency and apnea in very low birth weight (VLBW, <1500 g) preterm infants. Endotracheal intubation and mechanical ventilation carry many risks including potentially fatal air leaks and ventilator-associated pneumonias. Less invasive methods of respiratory support are needed to minimize these risks while supporting the convalescing preterm infant. This protocol will test the effectiveness of nasal high-frequency ventilation (NHFV) in stable neonates with mild respiratory acidosis who are dependent on nasal continuous positive airway pressure for respiratory support (CPAP). Nasal high-frequency ventilation may be effective in decreasing rates of reintubation for apnea or respiratory insufficiency in VLBW infants. Enrollment will include 60 stable VLBW infants who are currently being treated with nasal CPAP and who have mild respiratory acidosis. Twenty patients will be assigned to each ventilator under investigation. Nasal high frequency ventilation will be applied at the same mean airway pressure as the patients' previous CPAP support. The amplitude of the nasal high frequency ventilation will be adjusted to achieve adequate shaking of the chest wall. Blood gas measurements, continuous transcutaneous PCO2 monitoring, continuous pulse oximetry, and chest x-rays will be used to assess safety and efficacy. Study power has been calculated to detect a difference (drop or rise) in PCO2 of 8 torr, a clinically relevant diffe

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。经常需要长时间的机械通气来治疗非常低的出生体重（VLBW，<1500 g）早产儿的呼吸功能不全和呼吸暂停。气管插管和机械通气具有许多风险，包括潜在的致命空气泄漏和呼吸机相关的肺炎。需要减少呼吸支持的侵入性方法，以最大程度地降低这些风险，同时支持康复性早产儿。该方案将测试鼻高频通气（NHFV）在具有轻度呼吸酸中毒的稳定新生儿中的有效性，这些新生儿依赖于鼻连续呼吸道呼吸道支持（CPAP）。鼻高频通气可能有效地降低了VLBW婴儿呼吸暂停或呼吸不足的重新输入率。入学率将包括60名稳定的VLBW婴儿，他们目前正在接受鼻CPAP治疗，并且患有轻度呼吸道酸中毒。将向每个正在研究的呼吸机分配20名患者。鼻高频通风将以与患者先前的CPAP支持相同的平均气道压力应用。鼻高频通风的幅度将调整，以使胸壁充分摇动。血气测量，连续的经皮PCO2监测，连续的脉搏血氧饱和度和胸部X射线将用于评估安全性和功效。已经计算了研究能力以检测8 Torr的PCO2的差异（降低或上升），这是一种临床相关的差异