Clinical Epidemiologic and Biologic Studies of Donor Human Milk and Breastfeeding

供体母乳和母乳喂养的临床流行病学和生物学研究

• 批准号: 7898923
• 负责人: Tarah Trinity Colaizy
• 金额: $ 12.39万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898923
• 关键词: Age; Age-Months; Award; Behavior; Breast Feeding; Childhood; Chronic Disease; Clinical; Clinical Research; Data; Databases; Development; Diet; Dietary Intervention; Disease; Epidemiology; Goals; Growth; Head circumference; Health; Health Benefit; Hospitals; Human Milk; Hypertension; Infant; Infant Development; Infant formula; Institutes; Investigation; Iowa; Length; Length of Stay; Life; Low Birth Weight Infant; Measures; Mentors; Milk; Morbidity - disease rate; Mothers; Necrotizing Enterocolitis; Neonatal; Nutritional status; Outcome; Pediatric Hospitals; Perinatal Epidemiology; Pneumonia; Population; Predictive Factor; Premature Infant; Public Health; Quality of life; Randomized Controlled Trials; Research; Research Personnel; Safety; Sepsis; Survivors; Testing; Time; Training; Universities; Ventilator; Very Low Birth Weight Infant; Weight; cohort; disability; experience; feeding; fortification; high risk; infancy; obesity risk; peer; randomized trial; skills; success; therapy design

DESCRIPTION (provided by applicant): Breastfeeding is an important health-promoting behavior. Human milk is the ideal diet for all infants, optimizes intellect, and provides protection against infectious and atopic diseases in childhood as well as decreasing risks for obesity, hypertension and other chronic diseases. Infants with the highest risk of life-long disability, very low birthweight (VLBW) preterm infants, are breastfed at some of the lowest rates in the US. Maternal milk is not always available, and pasteurized donor human milk is an alternative that requires investigation. Whether donor milk conveys health and developmental advantages similar to those bestowed by maternal milk is unknown. By determining the effects of donor milk on health and developmental outcomes when compared to preterm infant formula, we seek to optimize outcomes in this fragile population. Term and late-preterm infants admitted to NICUs are breastfed at lower rates than healthy term infants. Understanding factors predictive of breastfeeding success in these populations is essential to designing interventions. This application describes a 5-year training plan to develop skills necessary for success as an independent neonatal epidemiology investigator. The PI is guaranteed at least 80% protected time to devote to research during this award. Extensive support has been given to the candidate by senior investigators both internal and external to the proposed research, and will continue. Drs. Saftlas and Morriss will sponsor and co-sponsor the Pi's training, and their respective expertise in perinatal epidemiology and large-database analysis will guide the Pi's efforts. The hypothesis of our donor milk research is that donor human milk offers health and developmental advantages similar to maternal milk in VLBW infants. The Pi's preliminary retrospective data show similar developmental outcomes in donor milk and maternal milk fed infants, leading to the following aims: 1) To conduct a randomized trial of donor human milk vs. preterm infant formula, to determine if short and medium-term health and developmental outcomes are enhanced by donor milk compared to formula; 2) To retrospectively compare growth through 18-22 months in preterm infants fed donor human milk compared with those fed maternal milk, with the hypothesis that growth is equivalent; 3) To determine factors predictive of breastfeeding success in the term and late-preterm populations admitted to NICUs, in order to design interventions to eradicate barriers.

描述（由申请人提供）：母乳喂养是一种重要的健康促进行为。人类牛奶是所有婴儿的理想饮食，优化智力，并为儿童时期的感染性和特征性疾病提供保护，并降低了肥胖，高血压和其他慢性疾病的风险。终身残疾风险最高的婴儿，非常低的出生体重（VLBW）婴儿，在美国的某些率最低的情况下母乳喂养。孕产妇并不总是可用的，巴氏杀菌供体牛奶是需要研究的替代品。供体牛奶是否传达了与母乳相似的健康和发展优势，这是尚不清楚的。与早产婴儿配方相比，通过确定供体牛奶对健康和发育结果的影响，我们试图优化这种脆弱人群的结果。接受NICUS的病女性和晚期婴儿的母乳喂养比健康的儿童接受母乳喂养。了解这些人群中母乳喂养成功的因素对于设计干预措施至关重要。该申请描述了一项为期5年的培训计划，以制定作为独立新生儿流行病学研究者成功所必需的技能。在此奖励期间，保证PI至少有80％的保护时间用于研究。拟议研究的内部和外部的高级调查员向候选人提供了广泛的支持，并将继续。博士。 Saftlas和Morriss将赞助和共同赞助PI的培训，以及他们在围产期流行病学方面的各自专业知识，大数据库分析将指导PI的努力。我们的捐赠牛奶研究的假设是，捐赠者人奶提供了与VLBW婴儿中母乳相似的健康和发育优势。 PI的初步回顾性数据显示，供捐赠牛奶和喂养婴儿的相似发育结果，导致了以下目的：1）进行供体供体的人牛奶与早产婴儿配方奶粉的随机试验，以确定与配方相比，捐赠者牛奶是否会增强短期和中期健康和中期的健康和发展量。 2）回顾性地比较了喂养供捐赠人牛奶的早产儿的生长，与喂养母乳相比，喂养供捐赠的人牛奶的生长，假设生长是同等的； 3）确定预测该期限内母乳喂养成功的因素，并确定了NICUS的晚期人群，以设计干预措施以消除障碍。