AUTOIMMUNE MECHANISMS IN DIABETIC NEUROPATHY

糖尿病神经病的自身免疫机制

• 批准号: 7376616
• 负责人: JOHN W WILEY
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376616
• 关键词: autoantibody; diabetes mellitus; diabetic neuropathy; nervous system; noninsulin dependent diabetes mellitus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The causes of long-term complications associated with type 2 diabetes mellitus are poorly understood. Previous studies suggest that patients with type 2 diabetes can develop autoimmune immunoglobulins (autoantibodies directed against their own tissues) during the course of their illness. We will examine the hypothesis that a significant percentage of patients with type 2 diabetes will slowly develop autoantibodies during the course of their illness and that these autoantibodies contribute to the injury and loss of cells in the nervous system, a well-known complication in long-term diabetic patients. Two groups of type 2 diabetic patients will be enrolled in this study. Group 1 will have the diabetes for three to four years at the time of enrollment. Group 2 will have had diabetes for seven to eight years at the time of enrollment. Both groups will undergo a thorough examination of their nervous system function and have blood drawn to screen for the presence of autoantibodies. All participants will undergo re-evaluation between three to four years after the initial testing. These studies will help to determine the significance of autoimmune mechanisms in the natural history of nerve injury that occurs in type 2 diabetes mellitus

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。与2型糖尿病有关的长期并发症的原因知之甚少。先前的研究表明，2型糖尿病患者可以在疾病过程中发展自身免疫球蛋白（针对其自身组织的自身抗体）。我们将研究以下假设：2型糖尿病患者在疾病过程中会慢慢发展自身抗体，并且这些自身抗体有助于神经系统中细胞的损伤和细胞丧失，这是长期众所周知的并发症糖尿病患者。这项研究将招募两组2型糖尿病患者。第1组将在入学时患有糖尿病三到四年。在入学时，第2组将患有糖尿病七到八年。这两组将对其神经系统功能进行彻底检查，并吸收血液以筛选出自身抗体的存在。所有参与者将在初次测试后的三到四年之间进行重新评估。这些研究将有助于确定自身免疫机制在2型糖尿病中发生的神经损伤自然史上的重要性